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Resveratrol and UV radiation - confused by 2 abstracts

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Joined: 21 Nov 2005
Posts: 105
Location: Taiwan

PostPosted: Sun Apr 15, 2007 8:00 am    Post subject: Resveratrol and UV radiation - confused by 2 abstracts Reply with quote

I found these two abstracts, but they appear (to my untrained brain) to contradict? Would you please explain what this means to the use of Resveratrol in skin care products.

"Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells.

Chen ML, Li J, Xiao WR, Sun L, Tang H, Wang L, Wu LY, Chen X, Xie HF.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410078, China.

OBJECTIVE: To observe the photoprotective effect and possible mechanisms of resveratrol for ultraviolet A (UVA) irradiated HaCaT cells. METHODS: HaCaT cells under UVA irradiation with 5J/cm(2) were interfered with 0.01 mmol/L and 0.1 mmol/L resveratrol. The testing objects were divided into a control and a UVA irradiation group, and then we detected the proliferation capacity with methylthiazdyl tetrazolium (MTT) and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, content of maleic dialdehyde (MDA) with hydroxylamine, colorimetric, thiobarbituric acid (TBA) methods. The ultrastructure was observed under electron microscope. RESULTS: Resveratrol could enhance the proliferation activity, SOD, GSH-Px activity of HaCaT cells under UVA irradiation, decrease the content of MDA in dose-dependent manner (P<0.05). The electron microscope revealed that resveratrol could relieve the injury of HaCaT cells' ultrastructure. CONCLUSION: Resveratrol can relieve the inhibition to HaCaT cell proliferation,injury of their ultrastructure and oxidation by UVA irradiation. The protection is dose-dependent. That resveratrol raises the oxidase activity and clears the oxyradical may account for these results."


"Resveratrol enhances UVA-induced DNA damage in HaCaT human keratinocytes.

Seve M, Chimienti F, Devergnas S, Aouffen M, Douki T, Chantegrel J,Cadet J, Favier A.

Laboratoire des Lesions des Acides Nucleiques, DRFMC/SCIB, CEA/Grenoble, Grenoble, France.

Resveratrol, a polyphenolic phytoalexin, is a very effective antioxidant that also exhibits strong antiproliferative and anti-inflammatory properties. Recent studies have provided support for the use of resveratrol in human cancer chemoprevention, in combination with either chemotherapeutic drugs or cytotoxic factors for a most efficient treatment of drug refractory tumor cells. Resveratrol is also widely used in topical preparations, as a chemoprotective compound against development of several cutaneous disorders, including skin cancer. Nevertheless, the combined effect of resveratrol and UVA irradiation on cellular toxicity and DNA damage has never been assessed. The aim of this work was to investigate the effect of resveratrol on cell fate in immortalized human keratinocytes HaCaT cells. The results indicated that resveratrol potentiates the production of significant amounts of 8-oxo-7,8-dihydro-2'-deoxyguanosine in UVA-irradiated genomic DNA. Moreover, the combination of resveratrol with UVA significantly enhances the induction of DNA strand breaks and cell death in HaCaT keratinocytes. The conclusion is a potential hazardous effect of topical application of resveratrol, particularly on regions exposed to sunlight."
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PostPosted: Sun Apr 15, 2007 2:56 pm    Post subject: Reply with quote

These article do not necessarily contradict. In the first, resveratol reduces MDA, which indicates decrease in lipid oxidation. In the second, it seems to potentiate certain kinds of DNA damage caused by UV light. These are different phenomena and both might occur (assuming other studies confirm these findings).
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Joined: 16 Aug 2007
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PostPosted: Sun Sep 09, 2007 10:27 am    Post subject: Reply with quote

Oh god, just wonderful! The sun lotion I use is made with a grapeseed oil base, which is just loaded with resveratrol. And I read this abstract after I make a bulk purchase. Go figure.
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