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ascorbyl glucoside?

 
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skincarefreak



Joined: 05 Aug 2005
Posts: 69

PostPosted: Sun Nov 27, 2005 9:05 pm    Post subject: ascorbyl glucoside? Reply with quote

I know that this is a derivative of vitamin C? I'm just wondering how effective is it in producing collagen. Dr. T have you heard anything about this derivative?
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drtodorov
Site Admin


Joined: 10 Dec 2004
Posts: 3099

PostPosted: Mon Nov 28, 2005 4:25 am    Post subject: Reply with quote

Well, apparently it is a derivative where ascorbyl entity is covalently bonded t o a molecule of glucose. I haven't seen any research on benefits of this particular derivative or lack thereof.

Generally, companies introduce new derivatives for one of the two reasons:

(1) a new derivative is superior in some way to the existing ones (e.g. boost collagen synthesis more, or penetrates better, or is more stable); or

(2) it is similar (no better) than the existing ones but because it is different, the products with it can be promoted as 'unique' or 'new and improved' and/or an exclusive patent can be obtained.

Unfortunately, without the research data, I cannot tell you what is going on in the case of ascorbyl glucoside.
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rileygirl



Joined: 05 Mar 2006
Posts: 17

PostPosted: Thu Mar 15, 2007 7:16 pm    Post subject: Reply with quote

Any updates on the ascorbyl glucoside yet?
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drtodorov
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Joined: 10 Dec 2004
Posts: 3099

PostPosted: Thu Mar 15, 2007 7:36 pm    Post subject: Reply with quote

I see only one new publication:

---------------------------------

Skin Res Technol. 2006 May;12(2):105-13.
Ultrasound enhanced skin-lightening effect of vitamin C and niacinamide.Hakozaki T, Takiwaki H, Miyamoto K, Sato Y, Arase S.
Department of Dermatology, School of Medicine, University of Tokushima, Tokushima, Japan. hakozaki.t.1@pg.com

BACKGROUND/PURPOSE: Cutaneous hyperpigmentation occurs in multiple conditions. There is a strong need for the improvement of hyperpigmentation especially among Asian women. However, the effect of existing skin-lightening agents is not sufficient. One reason attributes to the limited capability of active agents to be delivered transepidermally. Ultrasound is one promising approach to enhance transepidermal transport. In this work, we investigate the effect of the use of high-frequency ultrasound together with coupling gel containing skin-lightening agents (ascorbyl glucoside and niacinamide) on facial hyperpigmentation in vivo in Japanese women. METHODS: The effect of ultrasound on the absorption of skin-lightening agents into the stratum corneum was evaluated in a tape-stripping method on human forearms in vivo. The skin efficacy was assessed in a facial clinical trial involving 60 subjects with hyperpigmentation in a paired design. Subjects were assigned to two groups, each group using two treatments (one on each facial cheek): (1) skin-lightening gel with ultrasound vs. no treatment or (2) skin-lightening gel with ultrasound vs. skin-lightening gel treatment. Changes in facial hyperpigmentation were objectively quantified by computer analysis and visual grading of high-resolution digital images of the face in addition to the subjective assessment via questionnaire. RESULTS: Ultrasound radiation enhanced the absorption of skin-lightening agents in the stratum corneum in a radiation-time-dependent manner. In the facial clinical trial, use of ultrasound radiation together with the skin-lightening gel significantly reduced facial hyperpigmented spots compared with both no treatment and skin-lightening gel alone after 4 weeks. CONCLUSIONS: The data suggest that use of high-frequency ultrasound radiation together with skin-lightening gel is effective to reduce hyperpigmentation via enhancing transepidermal transport of skin-lightening agents.
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rileygirl



Joined: 05 Mar 2006
Posts: 17

PostPosted: Fri Mar 16, 2007 9:22 am    Post subject: Reply with quote

Thanks Dr. T. I was hoping for more, but that will have to do! :D
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KJB



Joined: 24 Oct 2007
Posts: 1
Location: Denve, CO

PostPosted: Wed Oct 24, 2007 5:01 pm    Post subject: Ascorbyl Glucoside Reply with quote

Hello,

Data shows that Ascorbyl Glucoside has been proven to be more stable (it will not turn color or go bad) and longer lasting in the skin than currently used Vitamin C Derivatives, but it retains the same anti-wrinkle, skin brightening and collagen stimulating effectiveness as the ones used now (like Sodium Ascorbyl Phosphate, Magnesium Ascorbyl Phosphate and Ascorbyl Palmitate). Because it lasts longer in the skin, you could go a few days without applying the product containing Ascorbyl Glucoside (or maybe you forget to bring it on a trip), and still see its benefits on your skin.

Hope that helps!

KJB
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drtodorov
Site Admin


Joined: 10 Dec 2004
Posts: 3099

PostPosted: Wed Oct 24, 2007 5:14 pm    Post subject: Reply with quote

Can you point to the data you are referring to?
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