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R-lipoic acid (reduced form)

 
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jamesherried



Joined: 07 May 2005
Posts: 764

PostPosted: Sat May 07, 2005 3:34 pm    Post subject: R-lipoic acid (reduced form) Reply with quote

Would this be the best way to use alpha-lipoic acid in a do-it-yourself formula? It comes in liquid softgels, so it doesn't have to be dissolved, and it's the R isomer in it's reduced form (R-Dihydro-Lipoic Acid). It's available thru the Life Extension Foundation.

"R"-Dihydro-Lipoic Acid
150 mg, 60 liquid capsules
Item Catalog Number: 683
Alpha lipoic acid consists of two different forms (isomers) that have vastly different properties. The R form is the biologically active component (native to the body) that is responsible for lipoic acids phenomenal antioxidant effect. The S form is produced from chemical manufacture and is not very biologically active. Alpha lipoic acid supplements consist of the R and S form in a 50/50 ratio. That means a 100 mg alpha lipoic acid supplement is providing 50 mg of the biologically active R form.

The human body normally produces and uses R-lipoic acid, the active form. R-lipoic acid significantly reduces inflammatory reactions and has been shown to be more potent than the combined R and S form that comprise alpha lipoic acid.31-40*

When alpha lipoic acid is ingested, it is first converted to its reduced form, R-dihydro-lipoic acid, where the main action of lipoic acid is initiated. R-dihydro-lipoic acid is the reduced (or active) form of R-lipoic acid. R-dihydro-lipoic acid produces the majority of the results attributed to R-lipoic acid and alpha lipoic acid. By consuming R-dihydro-lipoic acid, you are obtaining the form of R-lipoic acid that is immediately available to cells. R-dihydro-lipoic acid is only available in liquid capsules because it is itself a liquid and must be kept sealed from air.

For members who have been using Super Alpha Lipoic Acid capsules, Life Extensions R-Dihydro-Lipoic Acid liquid capsule provides a more effective form of lipoic acid. Each liquid capsule of R-Dihydro-Lipoic Acid supplement contains 150 mg of this lipoic acid form that provides greater biological activity compared to a 300 mg capsule of regular alpha lipoic acid.


References
Supplement Facts
Serving Size 1 liquid capsule

Servings Per Container 60

Amount Per Serving
R-dihydro-lipoic acid

150 mg

Other ingredients: gelatin, MCT oil, vitamin E, rosemary extract, ascorbyl palmitate.
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drtodorov
Site Admin


Joined: 10 Dec 2004
Posts: 3078

PostPosted: Sat May 07, 2005 4:51 pm    Post subject: Reply with quote

R-dihydro-lipoic acid is rather unstable and oxidizes very quickly. Dihydro-lipoic acid may not be the best form for topical use. In any case, the skin care studies have all been with lipoic acid, there's no data on topical use of dihydro-lipoic acid. While in theory, there may be some rational for using a mix of R-lipoic and R-dihydro-lipoic in skin care, it would be prudent to avoid R-dihydro-lipoic until there is some data on topical use.
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