EGF

[mimi]

I have been reading about Growth factor ..... ( protein being too large to penetrate skin & how fast it degrade.)
is this EGF effective for DIY ? www.skinactives.com/products/egf.htm

[drtodorov]

It might stimulate the epidermis, perhaps speed up cell turnover and thus act as an nonirritating exfoliant. It is unlikely to improve wrinkles since they are in the dermis.

[merton]

1) Its for wounded skin.

2) Find out the quantity your getting. It will be in microns or less. "Very small" is not a scientifically acceptable or economically comforting answer with any active under any circumstances.

[jamesherried]

Here is what one person posted on another forum (a different skincare website). She used the EGF from Skin Actives. But then after this I will post a reply made to her by someone else on the forum that seems to go against her enthusiasm for EGF. So I don't know what to make of this yet.

EGF is a miracle, although watch out for spots!
« Thread Started on Jun 30, 2006, 8:32pm »

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Heya all

I have been using SA Epidermal Growth Factor for two weeks now. I had very resilient dense, gorgeous skin when I was 14/15.
After trouble with inflammatory acne, and over scrubbing, abusing peels... the list is endless I have overcame this problem. However although my skin was now good it was dull, uneven, thinner, cant exfoliate without it hurting. I am now 20.

After 2 weeks, WOW!!! My skin is just like it was when I was 14/15, Can't wait to tell SA my gratitude. However because it ups the renewal cycle I noticed loose dead skin, I got a few pimples. This must be due to the dead skin blocking the pores.

Reccomendation :- If starting to use, up the exfoliating regimen!

Luv you all and cant wait to come back to skin actives.

[jamesherried]

this is a post from thr ytf beauty board by Pentacles gives us somthing to think about. SueM

Dr Huber's views on growth factors (TNS, Neocutis,etc) (Skincare (General))
posted by Pentacles, -- Friday, 07/14/06, 4:37 pm

Posted by Richard Huber on July 6, 2006, 5:24 pm, in reply to "Growth factors"
70.37.193.106

Growth factors are parts of proteins. They are very big polymers, reaching thousands and thousands of daltons in molecular weight - certainly larger than 750 molecular weight. This means they cannot penetrate the skin. Even if they could penetrate the stratum corneum by using ultrasound to force them deep, for example and suddenly found themselves at the door of an emerging cell, these polymer chemicals would be quite unwelcome. They would be regarded as invading substances and create an immediate inflammatory response. The histology in other words would not be going in the positive direction we want.

If you apply these long enough, they will generate more collagen and skin protein because the skin will try to protect itself from inflammation by making protein of a sort, but the new proliferation will not be sustained by increased vascularity and the skin follows a kind of addiction cycle - whenever you withdraw the product the skin will look depleted, usually within a day or two, and so you find yourself driving madly to the dermatologist or whomever to get another vial full.

Incidentally, rubbing your skin vigorously or using hot water will also increase collagen and skin protein, also not sustainable.

On the more worrisome questions of safety that you raise, I wouldn't think these would increase your susceptibility to skin cancer, because they are at worst, just irritants.

I think these products are good smoothing goop. Good for a Saturday Night Special - they smooth out the skin instantly, like egg white, but without the sticky feeling. But they cannot possibly enter into the metabolic cycle of the cell and promote true growth of tissue. So, from a safety standpoint, they just create an addiction response. I don't think that leads to skin cancer. On the other hand, it might be interesting to see the epigenetic aspects of these compounds. Maybe we'll run some assays and see for ourselves.

There could be a lot of unhappy faces in topical product land as this emerging science gets underway around the world. Studies will focus on individual chemicals and their effects on longevity genes.

I would use the growth promoting proteins sparingly. A good foundation powder can usually do a better job without the negative histology. Richard

[ionik]

I am currently using SAS Let's make collagen serum. This serum has EGF and natural peptides (I think by that they mean copper peptide). I am 30 and I started seeing some fine lines on my forehead. I've been applying this SAS serum to my forehead for 1 week. Then on top I've been applying my self-made cream with 8% Matrixyl in it. My forehead lines are vanishing. You can barely see them now even in the strong light! I can't tell which ingridient has the most effect here...
I've seen posts from other people on SAS forum about Let's make collagen serum about lines and wrinkles vanishing. I tend to think that EGF that they use in that serum is pretty powerful. I hope it is not too dangerous and cancerogenic since EGF stimulates rapid cell growth similar to the tumors :roll: :?:

[orangehrzn]

I've used the skinactives EGF on mild crows feet for a month. No effect whatsoever, nor it 'evens out skin'. Simply no observable effect.

[ionik]

crows feet is a hard one to fight since you keep smiling:) You might be better off using DMAE cream there. I try to control my forehead wrinkling movement now that I noticed wrinkles to appear. I try to avoid overactive facial expressions and crying is a big NO NO now.

SAS Let's make collagen serum contains not only EGF, but also Copper peptide, alpha lipoc acid, niacinamide, Sea Kelp Bioferment, L-carnosine and hyaluronic acid. Maybe there is a sinergistic effect there... Or possibly my self-made Matrixyl cream is working. I added 8% palmitoyl pentapeptide to the base Canvas cream together with coenzyme Q10. I am also going to add niacinamide and alpha lipoc acid there.

This week I will condact an experiment and use only my cream without the SAS serum. We will see what happens.