niacinamide

[guest]

niacinamide 2% : " in clinical studies it significantly decreased hyperpigmentation & increase skin lightness. the data suggest niacinamide is an effective skin lightening compound that works by inhibiting melanosome transfer from melanocytes to keratinocytes. "
I read this article & I am trying to find the clinical studies ? is niacinamide effective for hyperpigmentation ?

[drtodorov]

Well, there is indeed at least one research paper to the at effect. See below:

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.

Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE.

Research & Development Department, Procter & Gamble Far East, Inc., Kobe Technical Center 7F, Naka 1-17, Koyo-cho, Higashinada-ku, Japan.

BACKGROUND: Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agents. Niacinamide is a possible candidate. OBJECTIVES: To investigate the effects of niacinamide on melanogenesis in vitro and on facial hyperpigmentation and skin colour in vivo in Japanese women. METHODS: Melanin production was measured in a purified mushroom tyrosinase assay, cultured melanocytes, a keratinocyte/melanocyte coculture model, and a pigmented reconstructed epidermis (PREP) model. The clinical trials included 18 subjects with hyperpigmentation who used 5% niacinamide moisturizer and vehicle moisturizer in a paired design, and 120 subjects with facial tanning who were assigned to two of three treatments: vehicle, sunscreen and 2% niacinamide + sunscreen. Changes in facial hyperpigmentation and skin colour were objectively quantified by computer analysis and visual grading of high-resolution digital images of the face. RESULTS: Niacinamide had no effect on the catalytic activity of mushroom tyrosinase or on melanogenesis in cultured melanocytes. However, niacinamide gave 35-68% inhibition of melanosome transfer in the coculture model and reduced cutaneous pigmentation in the PREP model. In the clinical studies, niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use. CONCLUSIONS: The data suggest niacinamide is an effective skin lightening compound that works by inhibiting melanosome transfer from melanocytes to keratinocytes.

[guest]

is it possible to DIY ?

[drtodorov]

Possibly, but I haven't tested that

[Guest]

what si the difference between Niacinamide and Niacinamide Ascorbate

[drtodorov]

Niacinamide is a natural form of vitamin B3. Niacinamide ascorbate is a combo of B3 and ascorbic acid not found in nature. Perhaps it is useful, but I haven't seen any research on it. If you find any, please post.