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Base Creams and dermal penetration

 
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blaze



Joined: 23 Oct 2009
Posts: 12

PostPosted: Wed Feb 24, 2010 3:17 am    Post subject: Base Creams and dermal penetration Reply with quote

I have been reading a bit about actives penetrating the skin successfully.

Alot of base creams dont have anything to help these actives penetrate the skin effectively. Propylene Glycol and ethanol are effective carriers, but these arent in many base creams.

Does a regular over the counter really act as a carrier for active ingredients?

From my understanding things like Tetrahexyldecyl Ascorbate and Vitamin E Acetate absorb very easily into the skin, so those sorts of active would be fine in a standard base cream/lotion.

But what about other actives? Like water soluble ones etc?

I know DMI is said to be very beneficial in regards to assisting actives to effectively get to the target sources deep in the skin. But base creams do not contain it. It is something one has to add themselves.
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drtodorov
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Joined: 10 Dec 2004
Posts: 3256

PostPosted: Sun Mar 07, 2010 12:42 am    Post subject: Reply with quote

It's too complex a complex subject to be covered in a post. Generally speaking, most small fat soluble molecules penetrate well, even with ordinary bases. Other situations need to be discussed separately but typically small non-charged (under pH of use) molecules tend to penetrate better.
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blaze



Joined: 23 Oct 2009
Posts: 12

PostPosted: Wed Mar 10, 2010 4:06 am    Post subject: Reply with quote

thanks dr todorov.

Does Glycerin act as a carrier for actives like propylene glycol does?
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drtodorov
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Joined: 10 Dec 2004
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PostPosted: Wed Mar 10, 2010 6:06 pm    Post subject: Reply with quote

Not quite like propylene glycol but acceptable for many actives. However, some people find glycerin too sticky. On the positive side, it causes reactions less often than propylene glycol.

Last edited by drtodorov on Mon Mar 15, 2010 9:53 am; edited 1 time in total
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blaze



Joined: 23 Oct 2009
Posts: 12

PostPosted: Mon Mar 15, 2010 8:01 am    Post subject: Reply with quote

Yes Glycerin is sticky and heavy. But it is second on the ingredient list in the base cream im using.

I was just adding Niacinamide at 4% to Cerave Cream for its anti acne benefits. Would the Niacinamide absorb into the skin well with just cerave cream?
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drtodorov
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PostPosted: Mon Mar 15, 2010 9:54 am    Post subject: Reply with quote

Niacinamide is relatively well absorbed so this base should suffice.
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blaze



Joined: 23 Oct 2009
Posts: 12

PostPosted: Tue Mar 16, 2010 10:41 pm    Post subject: Reply with quote

Thank you Dr Todorov.
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scarlettanderson



Joined: 13 Oct 2017
Posts: 1
Location: Australia

PostPosted: Fri Oct 13, 2017 3:15 am    Post subject: Reply with quote

[quote="drtodorov"]It's too complex a complex subject to be covered in a post. Generally speaking, most small fat soluble molecules penetrate well, even with ordinary bases. Other situations need to be discussed separately but typically small non-charged (under pH of use) molecules tend to penetrate better.[/quote]

Thanks for sharing with us!
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