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dinamometro
Joined: 17 Dec 2004
Posts: 18
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 Posted: Mon Mar 07, 2005 4:05 am Post subject: R-lipoic acid |
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Dear Dr Torovov,
I have recently bought R-alpha lipoic acid, I've realized it says in small lettering D-form. What does this means?. Is this the form that is effective against inflamation?.
Thanks for your postings, they are very useful. |
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cjdavis
Joined: 24 Jan 2005
Posts: 191
Location: Atlanta
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| Posted: Mon Mar 07, 2005 5:51 pm Post subject: Re: R-lipoic acid |
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| dinamometro wrote: | Dear Dr Torovov,
I have recently bought R-alpha lipoic acid, I've realized it says in small lettering D-form. What does this means?. Is this the form that is effective against inflamation?.
Thanks for your postings, they are very useful. |
D and R are the same thing. When an organic molecule has a chiral center, the molecule can be either D (dextro, “right”) or L (levo, “left”) this can be used interchangeably with R and S. For some reason chemists tend to use D and L for specific types of molecules (i.e. amino acids) and R and S for others, but it is all the same. R-ALA is the form produced by the body and consequently is stereospecific in its pharmacological activity. (1). A majority of the studies using ALA used the racemic form (50% R and 50% S) but it logical to assume that the R form will result in a significant greater pharmacological effect than a racemic mixture so R-ALA should be superior as an anti inflammatory. Some studies indicate that the S form has no biological activity and in fact my limit the beneficial effects of the R form (2,3). A racemic mixture is still beneficial but the pure R form should probably be used if possible (in my opinion).
1. Lockhart B, Jones C, Cuisinier C, Villain N, Peyroulan D, Lestage P. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res 2000 Feb 14;855(2):292-7
2. Maitra I, Serbinova E, Tritschler HJ, Packer L. Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. Biochem Biophys Res Commun 1996 Apr 16;221(2):422-9
3. Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 1997 Jul;273(1 Pt 1):E185-91 |
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dinamometro
Joined: 17 Dec 2004
Posts: 18
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| Posted: Tue Mar 08, 2005 3:03 am Post subject: |
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| Thank you very much for your clear response :) |
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