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CoQ10 Quality

 
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Whisper9999



Joined: 16 Feb 2007
Posts: 93
Location: Sunny Southwest

PostPosted: Wed Feb 28, 2007 3:32 pm    Post subject: CoQ10 Quality Reply with quote

The Life Extension Foundation basically makes the claim that only their CoQ10 is truly effective. Here are some examples:

search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=1579&query=yeast%20japan%20CoQ10&hiword=COQ10C%20COQ10IS%20COQ10S%20CoQ10%20JAPA%20JAPANS%20YEAS%20YEASTA%20YEASTBASED%20YEASTS%20japan%20yeast%20

ďLife Extension purchases its ingredients from top-of-the-line European and Japanese pharmaceutical-grade suppliers. While the cost of these premium ingredients is higher than Chinese materials, we believe the proven biological effects of these pharmaceutical-grade nutrients justify using them. In the majority of cases, the pharmaceutical-grade supplements members obtain from Life Extension are priced lower than cheaper-grade Chinese ingredients that are increasingly saturating the American marketplace.Ē

ďAs mentioned earlier in this article, Life Extension adds important ingredients (such as tocotrienols to coQ10) to deliver a scientifically balanced formula. Commercial companies often have formulation deficits that could result in potential adverse effects.Ē

Isnít this mostly sales and marketing hype??

For example, I can probably buy 100 mg of CoQ10 at a well-known discount retailer that we all know and love compared to 30 mg with LEF.

Oh, and I canít find it, but somewhere LEF even claimed that only CoQ10 that was made in Japan with a special process that left CoQ10 as an unproven isotope or something like that. I guess what Iím asking is: is CoQ10 always CoQ10?
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drtodorov
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Joined: 10 Dec 2004
Posts: 3177

PostPosted: Thu Mar 01, 2007 12:16 am    Post subject: Reply with quote

CoQ10 is a relatively simple molecule w/o optically active centers, so it is not hard to synthesize and/or test. Whether your CoQ10 is 99.9% pure or 98% pure makes almost no difference as far as CoQ10 dose is concerned. However, depending on grade and method of synthesis, the impurities may differ. Some impurities are inert and can be ignored while others may have potential for interference or negative effects. So, without very detailed comparison of brands and their tech data sheets, it is hard to judge whether the differences are meaningful.

The are situation where grade/purity/isomer composition arguments are legitimate, but just as often, companies exaggerate their importance for promotional purposes.
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Whisper9999



Joined: 16 Feb 2007
Posts: 93
Location: Sunny Southwest

PostPosted: Thu Mar 01, 2007 1:00 pm    Post subject: Reply with quote

drtodorov wrote:
CoQ10 is a relatively simple molecule w/o optically active centers, so it is not hard to synthesize and/or test. Whether your CoQ10 is 99.9% pure or 98% pure makes almost no difference as far as CoQ10 dose is concerned. However, depending on grade and method of synthesis, the impurities may differ. Some impurities are inert and can be ignored while others may have potential for interference or negative effects. So, without very detailed comparison of brands and their tech data sheets, it is hard to judge whether the differences are meaningful.

The are situation where grade/purity/isomer composition arguments are legitimate, but just as often, companies exaggerate their importance for promotional purposes.


If you have time, I'd love to know what you mean by "optically active centers"...
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drtodorov
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Joined: 10 Dec 2004
Posts: 3177

PostPosted: Thu Mar 01, 2007 6:12 pm    Post subject: Reply with quote

Optically active center is typically a carbon atom with 4 bonds to different chemical groups so that mirror image of such molecule cannot be superimposed on the original. Such mirror image molecules are called optical isomers and typically only one is biologically effective, e.g. L-ascorbic acid is active (as collagen synthesis booster) which D-ascorbic acid is not.
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