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Dr. Todorov - what MW is best for topical HA

 
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jands



Joined: 21 Nov 2005
Posts: 105
Location: Taiwan

PostPosted: Thu Mar 13, 2008 8:31 am    Post subject: Dr. Todorov - what MW is best for topical HA Reply with quote

Dr. T, you have written that "It [HA] will likely not penetrate into dermis in significant amounts."

Would a low molecular weight NaH powder be able to create an HA product that could penetrate into the dermis.

If so, how low a molecular weight would be needed?
Would something like 50K daltons be appropriate?
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drtodorov
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Joined: 10 Dec 2004
Posts: 3177

PostPosted: Thu Mar 13, 2008 10:38 pm    Post subject: Reply with quote

Size is only one factor that affects penetration. But, all things being equal, smaller sizes are likely to penetrate better. 50 kDa is still too large for good penetration but some penetration (via gaps between keratinocytes) might occur at that size, so it may be worth a try. But you'll need to balance pH of NaH to neutral, etc. If you like, send me a small sample of low MW NaH, I'll take a look how it behaves. Have you seen even lower weights available?
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