Can hylauronic acid be bad for your skin in the long run?

[Discohouse]

Dr. Todorov, can I ask your opinion on this matter:
Can hylauronic acid be bad for your skin in the long run? I would like to know whether there is any reliable evidence to prove so otherwise? I also wonder whether the same could be said about a 24 hour moisturizer, in that it might slow down or stop the normal flow of keratinocytes to the skin.

I would like to know whether the same could be said about moisturizing with biological oils, such as emu oil and squalane. Could they also wet the outer layers of the skin too much? Or can only water do this?

I am sorry for all the questions.

Your advise would be very much appreciated beyond words.

I ask this because according to another doctor, Dr. Pickart, the doctor who discovered the GHK-Cu peptide, he said on his online forum the following:



Dr. Pickart said this:
healthyskin.infopop.cc/eve/forums/a/tpc/f/1550055903/m/1191054946?r=3791007356#3791007356

"I don't recommend HA (hyaluronic acid)


Hyaluronic acid (scientifically named "hyaluronan") is a sugar-like molecule that can bind huge amounts of water (1000-fold of its own weight).

When applied to the surface of human skin, it feels smooth and sensuous but will slowly wets the skin's outer protective proteins and damages the skin barrier. This can temprarily improve the looks of skin but does not help skin health. The outer layer of skin (what we actually see) is composed of keratinocytes. The signal that causes the skin to send new keratinocytes to the skin's surface is a dryness in the outer layers of the skin. Hydrating (wetting) the outer skin proteins slows or even stops the normal flow of keratinocytes to the skin surface. If the skin is kept wet, such as by using hyaluronan, the skin renewal is slowed and skin ends up looking older.

Skin Damaging Cosmetic Moisturizers are designed to push water into the skin and wet the outer skin proteins. Various detergents (but they may not be called detergents) and water-holding molecules such as hyaluronic acid often used to loosen the outer skin proteins so water can interact with them. But this weakens the skin barrier and lets in viruses, bacteria, and allergens.

In about 1997, there were studies from Denmark that found that oil/water skin moisturizers broke down the skin barrier. The concern was that this could increase infection in hospital patients. Since then, it has been found that

This means to skin is more slowly replaced and damage remains longer. Cosmetic moisturizers are designed to wet the outer skin proteins and push water into the skin to puff it up. Various detergents (but they may not be called detergents) are used to loosen the outer proteins so water can interact with them. The best example is the "cold creams" that women applied every night in the 1930s and 1940s. You may have seen these in old movies. Their skin was kept moist but the women ended with horrible wrinkles.

Various polymers of hyaluronan are used as skin injectable skin fillers. Injectable form of hyaluronic acid are sold as "not-from-animals" but they are from pathogenic bacteria. The FDA warns that the material contain small amounts of bacterial protein and this can produce allergic responses in time."

[drtodorov]

There is a certain optimal level of moisture in the skin, including epidermis and stratum corneum, and there is a certain optimal level of epidermal renewal. Just like it is not optimal to have the skin that it "too wet" it is as bad or worse to have the skin that is chronically and excessively dry. The key is not how much ones moisturizes both whether skin is in the optimal range. People with normal or oily skin, don't generally need to moisturize all the time. On the other hand, people with persistently try skin tend to benefit from moisturizing. However, keep in mind that dry skin is often a result of lack of sebum (oily secretion) not from lack of water in the skin. Hence, for many people, products with emollients may be more effective that those with humectants.

[Discohouse]

Dr. Todorov, so I guess it would be better to use oils than water holding molecules and/or humectants such as hylauronic acid, sodium pca, and possibly glycerin if used in high amounts... I understand how emollients might be better for your skin, but I would like to know whether they too could potentially damage the skin if used too much as well?

Which leads me to this question as well: how do moisturizers such as Aveeno work rank in terms of how good they can be for one's skin since they seem to condition the skin by forming a film with dimethicone (I guess more "natural" skin lotions tend to use cera alba "wax" instead), as well as using conditioning agents such as "distearyldimonium chloride" to stick onto the skin? Could this too potentially trap too much water onto the skin, especially if used just after taking a shower, and be damaging to the skin for those individuals who are NOT suffering from chronic dryness?

[LoveBuzz]

Good questions and I too would like to know the answer.

Ever since taking Accutane my skin has been a bit dry. I've tended to use emu oil morning and nights. I also use MitoQ which is glycerin based, and home made CE Ferulic which is based on HA serum.

I'm wondering what I can do now to get around this. I could remove the HA from the CE Ferulic no problem. But would the glycerine be an issue too?

[drtodorov]

Things like Aveeno, used sparingly, are sometimes quite effective for very dry skin or in very dry environments. Under more normal conditions and for moderately dry skin it may be worth trying something more natural (and "indigenous" to the skin) like ceramides and/or sodium PCA

[Discohouse]

[LoveBuzz]

[LoveBuzz]

[drtodorov]

hydroxymethyl cellulose is cellulose chemically modified to be hydrophilic, which makes it suitable as a thickening agent in aqueous solutions. It is usually well tolerated and often used in cosmetics. It does not have skin benefits as an active ingredient but can be used as a thickener, including in vitamin C serums. However, acidic environment created by ascorbic acid might cause slow acid hydrolysis of hydroxymethyl cellulose, so you would want to store such serum in the freezer or at least in refrigerator.

smartskincare.com/treatments/topical/betaglucan.html

[Discohouse]