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Mike
Joined: 29 Sep 2006
Posts: 121
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 Posted: Fri Sep 29, 2006 10:49 pm Post subject: Buffering Glycolic Acid with Ammonium Hydroxide |
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Dr T,
What are the advantages and disadvantages of having a glycolic acid prodcut buffered with ammonium hydroxide?
Thanks for your time!
Mike |
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drtodorov
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Joined: 10 Dec 2004
Posts: 3177
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| Posted: Sat Sep 30, 2006 8:54 pm Post subject: |
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| What do you intend to use it for? |
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Mike
Joined: 29 Sep 2006
Posts: 121
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| Posted: Sat Sep 30, 2006 9:57 pm Post subject: |
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| My intention was to use it for acne in some people and for exfoliation in others. My understanding is that glycolic acid can help empty pores which are filled with sebum, bits and pieces of stratum corneum and a whole host of things which tend to cause the pore to develop a plug. For those folks that don't have acne, I was hoping that the glycoic acid would benefit the dermis, especially if the skin was pretreated with salicylic acid. How does buffering the pH (increasing the pH) of glycolic acid affect it's function? |
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drtodorov
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Joined: 10 Dec 2004
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| Posted: Sun Oct 01, 2006 2:08 am Post subject: |
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| For acne AHA do not seem to provide additional benefit if added to AHA. For exfoliation, BHA do not seem to provide additional benefit if added to AHA. |
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Mike
Joined: 29 Sep 2006
Posts: 121
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| Posted: Sat Oct 21, 2006 10:31 pm Post subject: |
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| Does buffering the Glycolic acid negate the effect of increasing the percentage of Glycolic acid? In other words, if the final product is going to have a pH of about 4.0, does it make any difference if the percentage of glycolic acid is 10% vs 15% vs 20% or more? |
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drtodorov
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Joined: 10 Dec 2004
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| Posted: Sat Oct 21, 2006 11:03 pm Post subject: |
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| Probably partly but not entirely. It seems that skin effects of AHA are the result of both pH and the specific activity of anion (at least as far as lactic and glycolic acids are concerned). |
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Mike
Joined: 29 Sep 2006
Posts: 121
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| Posted: Sat Oct 21, 2006 11:18 pm Post subject: |
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Is there an ideal pH for products that are not intended to be uses as exfoliants? Or would the ideal pH be dependent on the active ingredient that you are trying to get into the dermis?
Thanks for your time!
Mike |
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drtodorov
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| Posted: Sun Oct 22, 2006 12:41 am Post subject: |
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| Ideal pH depends on what skin can tolerate and what active ingredients are used. Each active ingredient has its own dependency of ionization state on pH, which affects penetration. If you are not concerned about exfoliation or penetration of actives (or actives are lipophilic), then you should match the pH of the skin's acid mantle (4 to 5.5). |
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Gabrieljon
Joined: 12 Apr 2016
Posts: 1
Location: Estonia
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| Posted: Sat Apr 16, 2016 5:54 am Post subject: Buffering Glycolic Acid with Ammonium Hydroxide |
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| anyone else tried glycolic acid to prevent breakouts and help scars fade and heal fast? |
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