Smart Skin Care Forums
Home  -   Forum Index  -   Search  -   Register  -   Profile  -   Log in  -   FAQ  -   Contact Us

TIMP-2 - I don't know where to post this

 
Post new topic   Reply to topic    Smart Skin Care Forum Index -> Copper Peptides
View previous topic :: View next topic  
Author Message
merton



Joined: 12 Mar 2006
Posts: 80

PostPosted: Mon Mar 13, 2006 5:13 pm    Post subject: TIMP-2 - I don't know where to post this Reply with quote

I must have missed an entire episode. Seemingly inaccessble thru the site: makingcosmetics.com

up popped a reference begining with this:

Description: biotechnologically produced protein called TIMP2 (tissue inhibitor of metalloproteinase 2) able to inhibit MMP-2 (matrix metalloproteinases 2) that degrade collagen in the skin. [] Clear, colorless liquid, pH 7-8. Soluble in water. for sale.

Wasn't this the category recently the exclusive domain of a doxycycline analog?

Dr. T, Is this stuff something to avoid?

Thank you,
-merton
Back to top
View user's profile
drtodorov
Site Admin


Joined: 10 Dec 2004
Posts: 3177

PostPosted: Mon Mar 13, 2006 11:10 pm    Post subject: Reply with quote

As far as I know, TIMP2 is a protein and is not likely to penetrate on topical application, this making even potential effectiveness questionable.

I suppose if one were to chop up TIMP2 into peptides, and activity was still retained by one of those small peptides, then such a peptide could be used instead, with a greater chance of penetration. But that's a speculation.
Back to top
View user's profile Send e-mail
merton



Joined: 12 Mar 2006
Posts: 80

PostPosted: Wed Mar 15, 2006 9:00 am    Post subject: Distributor's Explaination of TIMP2 product Reply with quote

Hi Dr. Todorov,

Apparently this product is patented as PEPHA TIMP and distributed by Center Chem, Inc. who is also the exclusive US distributor for Argireline. Their site explaining their position is here:

http://www.centerchem.com/Capability.asp?CapabilityID=3340&Cat1ID=20&Cat2ID=10

and their is a small icon on that page that leads to an illustrated explaination. Here is the direct link to the pdf file that you would get to from that ICON. [Duplicity is because I'm not sure this second link would work]:

http://www.centerchem.com/PDFs/PEPHA-TIMP%20Product%20Description.pdf

I'm not well versed enough at this point regarding this to comment but would appreciate any imput you can give on this issue. Its a scheduled obsession in a lineup from the interest generated by your infopacks.

[I also have to admit personal potential distortion of objectivity now that I'm aware of distributor because I've had favorable interaction with this company. Its not conscious but the possibility is there].

That said what is your evaluation of the claims of the manufacturer in the .pdf?

Thank you,
-merton
Back to top
View user's profile
drtodorov
Site Admin


Joined: 10 Dec 2004
Posts: 3177

PostPosted: Wed Mar 15, 2006 1:22 pm    Post subject: Reply with quote

I can't open their PDF, and without it i can't add anything specific to what I said above.
Back to top
View user's profile Send e-mail
merton



Joined: 12 Mar 2006
Posts: 80

PostPosted: Wed Mar 29, 2006 12:35 am    Post subject: TIMP2 Reply with quote

Hi Dr. Todorov,

It wasn't copyright so I emailed it to you as a .gif file. Did you recieve it? I've had some bounceback emails.

Thank you,
-merton
Back to top
View user's profile
drtodorov
Site Admin


Joined: 10 Dec 2004
Posts: 3177

PostPosted: Wed Mar 29, 2006 1:06 am    Post subject: Reply with quote

No, I haven't. If you downloaded their PDF, try emailing it to me, perhaps I can open it as attachment.
Back to top
View user's profile Send e-mail
merton



Joined: 12 Mar 2006
Posts: 80

PostPosted: Thu Mar 30, 2006 11:40 pm    Post subject: Sent as .PDF Reply with quote

Hi Dr. Todorov,

I resent it as a .pdf to your yahoo mailbox as an attachment. But I got to the .pdf by clicking on the first link in my post above. The link is not broken. I have the free adobe 7.0. There's a toolbar with the file name on it at the centerchem site. So one way or another you should have it. If not you may need to update adobe. I know you have a better version than I do. Is the yahoo email the one you check?
Back to top
View user's profile
drtodorov
Site Admin


Joined: 10 Dec 2004
Posts: 3177

PostPosted: Fri Mar 31, 2006 1:02 am    Post subject: Reply with quote

I was able to open it now, thanks.

It is a legitimate approach to try to use TIMP-2 inhibitor to prevent collagen breakdown but TIMP-2 is a protein, so skin penetration may be problematic. Whether their liposomal vehicle provides acceptable penetration and stability for TIMP-2 in real people is unclear, there were no human studies. Until good human studies are avaialable it is hard to say whether this works.
Back to top
View user's profile Send e-mail
Display posts from previous:   
Post new topic   Reply to topic    Smart Skin Care Forum Index -> Copper Peptides All times are GMT - 5 Hours
Page 1 of 1

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2005 phpBB Group