In vivo three-dimensional birefringence analysis shows collagen differences between young and old photo-aged human skin.

Author: Sakai S, Yamanari M, Miyazawa A, Matsumoto M, Nakagawa N, Sugawara T, Kawabata K, Yatagai T, Yasuno Y

Author affiliation: Basic Research Laboratory, Kanebo Cosmetics Inc., Kanagawa, Japan. sakai.shingo@kanebocos.co.jp

Publication date & source: 2008.07, J Invest Dermatol., 128(7):1641-7. Epub 2008 Feb 7.

Polarization-sensitive optical coherence tomography (PS-OCT) permits non-invasive visualization of dermal birefringence, mainly due to collagenous structures. The purpose of this study is to use PS-OCT to assess intrinsic-age-related and photo-age-related differences in three-dimensional dermal birefringence. We measured dermal birefringence of the cheek skin and photo-protected interior upper arm skin from old and young volunteers. The algorithm that we used automatically produces the transversal dermal birefringence map from the polarization-sensitive OCT volume. This allowed quantitative comparison and visualization of the transverse distribution of the dermal birefringence. We found that dermal birefringence of the cheek skin was significantly smaller in the old group than in the young group (young group, 0.295+/-0.037 degrees microm(-1); old group, 0.207+/-0.03 degrees microm(-1); P=0.003), whereas the interior upper arm showed no age-dependent difference. The transversal map of the cheek showed a heterogeneous decrease in dermal birefringence due to photoaging. The maps suggested that the peripheral regions of some infundibula were surrounded by a strong collagen network. Three-dimensional analyses of dermal birefringence using PS-OCT help to quantify the diagnosis of photoaging.

Indexes of Skin Care Research Abstracts by Subject Category Most Recent

Web SmartSkinCare.com

Home | About Us | Contact Us | Ask a Question | Resources

Copyright © 1999-2009 by Dr. G. Todorov / SmartSkinCare.com
Site Disclaimer | Copyright Certification