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You are here: Skin Care Research >
Author: Thibault PK, Wlodarczyk J, Wenck A
Author affiliation: Central Vein and Cosmetic Medical Center, Broadmeadow, New South Wales, Australia.
Publication date & source: 1998.05, Dermatol Surg., 24(5):573-7
Publication type: Clinical Trial; Randomized Controlled Trial
BACKGROUND: Low-strength daily formulations of glycolic acid are widely promoted for the treatment of photoaging. However, there are few clinical studies that objectively confirm the benefits of such formulations. OBJECTIVE: The purpose of this study was to determine the effectiveness of a 5% unneutralized formulation of glycolic acid in the treatment of facial and neck photoaging. METHODS: Seventy-five volunteers were recruited to take part in this double-blind randomized placebo-controlled clinical study. Participants applied either the 5% glycolic acid cream or the placebo cream to the face and neck for a period of 3 months. Pre- and posttreatment clinical assessments of photoaging effects were made by the same physician and were analyzed for statistical significance. RESULTS: Overall there were trends towards greater improvement or less worsening in the glycolic acid group for all clinical assessments for photoaging. There was statistically significant improvement favoring the active-cream in general skin texture and discoloration. There was a trend favoring glycolic acid in reduction of wrinkles, but this did not achieve statistical significance. CONCLUSION: Unneutralized 5% glycolic acid topical cream when used on a regular daily basis can improve some photoaging effects.
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