Skin care research: The effect of botulinum toxin type A on full-face intense pulsed light treatment: a randomized, double-blind, split-face study.

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The effect of botulinum toxin type A on full-face intense pulsed light treatment: a randomized, double-blind, split-face study.

Author: Khoury JG, Saluja R, Goldman MP

Author affiliation: Dermatology/La Jolla Inc and La Jolla Spa MD, La Jolla, California 92037, USA.

Publication date & source: 2008.08, Dermatol Surg., 34(8):1062-9. Epub 2008 May 6.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

BACKGROUND: Botulinum toxin type A (BTX) is commonly used in combination therapy, and it has been reported that periocular BTX treatment enhances the aesthetic improvements attained with intense pulsed light (IPL). OBJECTIVE: The objective was to evaluate if intradermal BTX treatment of the cheeks also enhances the efficacy of IPL. METHODS AND MATERIALS: Fifteen females enrolled in this prospective, randomized, double-blind, split-face study (14 completed, 1 lost to follow-up). All received standard IPL treatment and were randomly assigned to receive eight 0.1-mL intradermal injections of BTX (BOTOX Cosmetic, Allergan) in one cheek (8 U total dose) and eight injections of saline in the contralateral cheek. Small wrinkles and fine lines, erythema, hyperpigmentation, apparent pore size, skin texture, and overall appearance were evaluated for 8 weeks. RESULTS: A significantly higher proportion of patients showed improvement in small wrinkles and fine lines with IPL plus BTX than IPL plus saline--93% versus 29% at Week 4 (p=.003). Adjunctive BTX also achieved a greater degree of improvement in erythema (although statistical significance was not achieved). Other efficacy measures showed comparable improvements with both regimens. CONCLUSION: The adjunctive use of BTX enhances the improvement in small wrinkles and fine lines, and possibly erythema, achieved with IPL alone.

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