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You are here: Skin Care Research >
Author: Lupo MP, Smith SR, Thomas JA, Murphy DK, Beddingfield FC 3rd
Author affiliation: The Lupo Center for Aesthetic and General Dermatology, Orleans, LA 70124, USA. drlupo@drmarylupo.com
Publication date & source: 2008.01, Plast Reconstr Surg., 121(1):289-97.
Publication type: Comparative Study; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
BACKGROUND: With the baby boomer generation firmly ensconced in middle age and the ubiquity of botulinum toxin type A, nonsurgical facial rejuvenation is becoming increasingly prevalent. As this generation continues to age, products with greater therapeutic power to correct aging changes will be in growing demand. METHODS: A multicenter, double-blind, randomized, within-subject, controlled study was conducted comparing Juvederm Ultra Plus hyaluronic acid filler with bovine collagen. A subset of subjects classified as having treatment for severe nasolabial folds is presented in this article. Subjects received Juvederm Ultra Plus in one severe nasolabial fold and Zyplast collagen in the other nasolabial fold; up to two touch-up treatments were allowed at 2-week intervals. Nasolabial fold severity was evaluated every 4 weeks for 24 weeks using a five-point scale. Treatment site reactions and adverse events were also recorded. A complimentary treatment was offered at the end of the trial, with effectiveness evaluations just before retreatment and up to 48 weeks after repeated treatment for a subset of subjects. RESULTS: Of the 87 subjects, most were female Caucasians, but all Fitzpatrick skin types were represented (36 percent types IV through VI). At 24 weeks, 96 percent of nasolabial folds treated with Juvederm had maintained clinically significant correction, and 81 percent maintained the correction for 1 year or more. Results were similar for those subjects with follow-up through 48 weeks after repeated treatment. The median volume required for repeated treatment with Juvederm was significantly less than that for initial treatment (0.7 ml versus 1.6 ml). CONCLUSION: Juvederm Ultra Plus provides correction of severe nasolabial folds through 1 year or more.
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