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You are here: Skin Care Research >
Author: Hsu TS, Zelickson B, Dover JS, Kilmer S, Burns J, Hruza G, Brown DB, Bernstein EF
Author affiliation: thsu@skincarephysicians.net
Publication date & source: 2005.01, Dermatol Surg., 31(1):1-9.
Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial
OBJECTIVE: The objective of this study was to assess the safety and efficacy of a 585 nm flashlamp pulsed-dye laser for the nonablative treatment of facial rhytides. METHODS: A multicenter prospective randomized controlled study on 58 volunteers was performed. A split-face approach was adopted, with one periorbital region acting as a control and the other receiving either one or two treatments. Patients were photographed and imaged three-dimensionally before and after treatment. Histologic sections were analyzed. RESULTS: Three-dimensional topographic evaluation showed improvements of 9.8% (p = .0022) and 15% (p = .0029) in surface roughness for single and double treatments, respectively. Histology revealed an increase in type I collagen messenger ribonucleic acid expression, type III procollagen, chondroitin sulfate, and grenz zone thickness. Two treatments resulted in greater improvement than one treatment. CONCLUSION: Clinical improvement was achieved following a single treatment. Further improvement was observed following a second treatment. The subjective evaluation of clinical improvement was consistent with both histologic and topographic quantitative measurements.
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