Novel approach to the treatment of hyperpigmented photodamaged skin: 4% hydroquinone/0.3% retinol versus tretinoin 0.05% emollient cream.

Author: Draelos ZD

Author affiliation: Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. zdraelos@northstate.net

Publication date & source: 2005.07, Dermatol Surg., 31(7 Pt 2):799-804.

Publication type: Clinical Trial; Randomized Controlled Trial

BACKGROUND: Mild to moderately photodamaged skin is characterized by dyspigmentation, fine wrinkles, and tactile roughness. An optimal approach to the topical treatment of photoaging would simultaneously address all appearance issues. OBJECTIVE: This study was undertaken to evaluate the effect of 4% hydroquinone and 0.3% retinol in photoaging. MATERIALS AND METHODS: A 16-week study was designed to evaluate the efficacy and tolerance of a single cream containing prescription topical 4% hydroquinone for dyspigmentation and the cosmeceutical 0.3% retinol for fine wrinkles in an emollient vehicle for tactile roughness. This novel formulation was compared with 0.05% tretinoin emollient cream, the standard against which all other topical photoaging treatments are compared. Investigator assessments, subject assessments, and photography represented the evaluation end points. RESULTS: The cosmeceutical emollient 4% hydroquinone/0.3% retinol cream more effectively diminished the collective signs of photodamage than 0.05% tretinoin emollient cream in terms of dyspigmentation, fine wrinkles, and tactile roughness in 16 weeks. CONCLUSION: Combination therapy of hydroquinone and retinol may improve photoaging-associated hyperpigmentation.

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