A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma.

Author: Ferreira Cestari T, Hassun K, Sittart A, de Lourdes Viegas M

Author affiliation: Department of Dermatology, Federal University of Rio Grande do Sul--Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. tcestari@hcpa.ufrgs.br

Publication date & source: 2007.03, J Cosmet Dermatol., 6(1):36-9.

Publication type: Comparative Study; Multicenter Study; Randomized Controlled Trial

The aim of this study was to compare the efficacy and safety of a triple combination (TC) cream and monotherapy with hydroquinone (HQ) cream in the treatment of moderate to severe facial melasma. A total of 120 patients applied TC cream once daily or HQ cream twice daily for 8 weeks. Evaluations included static global severity assessment of melasma, improvement of melasma over time, local tolerability, and adverse events. TC cream was significantly more effective than HQ cream from week 4 onwards: lesions were approximately equivalent to the surrounding skin in 35% of all TC-treated patients, compared to 5% of those who used HQ cream (P = 0.0001). Improvement of more than 75% was achieved by 73% of TC cream patients and 49% of HQ cream patients (P = 0.007). The incidence of adverse events (erythema, burning sensation, and desquamation) was similar in both groups. No patient dropped out of the study because of drug-related adverse events. TC cream was more effective than the HQ cream for the treatment of moderate to severe facial melasma. Both products had similar safety profiles.

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