Effect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s) on skin aging: penetration, skin tissue production and fibrillogenesis.

Author: Fodil-Bourahla I; Bizbiz L; Schoevaert D; Robert AM; Robert L

Author affiliation: Laboratoire universitaire de recherche en ophtalmologie, faculte de medecine Broussais-Hotel Dieu, Universite Pierre-et-Marie-Curie (Paris 6), 1, place du Parvis Notre Dame, 75181 Paris cedex 4, France.

Publication date & source: 2003.07, Biomed Pharmacother, 57(5-6):209-15

Skin thickness is decreasing with age. This loss concerns both dermis and epidermis, cells and extracellular matrix. We could show here that percutaneous application of an L-fucose-containing preparation produced an increase of skin thickness and a densification of collagen bundles. We also could show that 3H-L-fucose penetrates in the dermis, a prerequisite for the above mentioned favorable pharmacological activities. These results, together with the previous favorable activities on the downregulation of matrix-degrading enzymes, free radical scavenging and increased cell proliferation confirm the favorable action of fucose and fucose-rich polysaccharides (FROP-s) on the skin by slowing down its aging.

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