Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.

Author: Uhoda I, Faska N, Robert C, Cauwenbergh G, Pierard GE

Author affiliation: Unit of Dermocosmetology, Department of Dermatopathology, University Medical Center of Liege, CHU Sart Tilman, B-4000 Liege, Belgium.

Publication date & source: 2002.08, Skin Res Technol., 8(3):164-7.

Publication type: Clinical Trial; Randomized Controlled Trial

BACKGROUND/AIMS: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. METHODS: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. RESULTS: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. CONCLUSION: The DMAE formulation under investigation increased skin firmness.

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