Clinical, histologic, and ultrastructural changes after nonablative treatment with a 595-nm flashlamp-pumped pulsed dye laser: comparison of varying settings. [2004.07]
CONCLUSION: Nonablative dermal remodeling can be accomplished with not only a variety of different technologies, but also with the same laser using markedly different settings.
A double-blinded randomized trial testing the tolerability and efficacy of a novel topical agent with and without occlusion for the treatment of cellulite: a study and review of the literature. [2004.07]
Cellulite is the unsightly dimpling and nodularity frequently found on the thighs and buttocks of post-adolescent women. The anatomy and pathophysiology of this unwanted condition is poorly understood...
Activation of latent transforming growth factor beta 1 and inhibition of matrix metalloprotease activity by a thrombospondin-like tripeptide linked to elaidic acid. [2004.06.01]
Impaired wound healing and skin aging are characterized by neutral protease-mediated destruction of matrix macromolecules associated with disturbance in tissue repair.
Treatment of neck lines and forehead rhytids with a nonablative 1540-nm Er:glass laser: a controlled clinical study combined with the measurement of the thickness and the mechanical properties of the skin. [2004.06]
BACKGROUND: Nonablative remodeling has been recently proposed as a new, no-down-time, anti-aging treatment. Objective. The objective was to evaluate the efficacy and safety of nonablative skin remodeling with a 1540-nm Er:Glass laser on neck lines and forehead rhytids... CONCLUSION: This study demonstrates that irradiation with a 1540-nm Er:Glass laser emitting in a pulsed mode and coupled with an efficient contact cooling system increases dermal thickness and firmness, leading to a clinical improvement of neck lines and forehead rhydits.
The pathophysiology of acne vulgaris in children and adolescents, Part 1. [2004.06]
Microcomedones, the earliest lesions of acne, appear at adrenarche, which typically occurs at about 8 years of age when androgens of adrenal origin begin to stimulate follicular hyperkeratosis and sebaceous hyperplasia in pilosebaceous units on the face.Optimal treatment for this disorder will address these various pathophysiologic factors.
Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized, parallel-group study. [2004.06]
OBJECTIVES: To compare the efficacy and tolerability of tazarotene 0.1% cream and tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin... CONCLUSIONS: Tazarotene 0.1% cream can offer superior efficacy over tretinoin 0.05% emollient cream in the treatment of facial photodamage, particularly with respect to the speed of improvement.
Responses of black and white skin to solar-simulating radiation: differences in DNA photodamage, infiltrating neutrophils, proteolytic enzymes induced, keratinocyte activation, and IL-10 expression. [2004.06]
Black skin is more resistant to the deleterious effects of ultraviolet radiation than white skin... Our data could provide an explanation as to why black skin is less susceptible to sunburn, photoaging, and skin carcinogenesis.
Pulsed dye laser therapy for rosacea. [2004.06]
Rosacea is a chronic and progressive inflammatory skin disorder affecting the facial convexities for which no curative measure is currently available. Forty consecutive patients with rosacea were treated with the Cynosure PhotoGenica V pulsed dye laser...
Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea. [2004.06]
A photographic analysis was conducted of results from a randomized, double-blind, vehicle-controlled, 12-week study that assessed the efficacy of topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) versus vehicle in the treatment of rosacea... These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea.
Objective changes in brow position, superior palpebral crease, peak angle of the eyebrow, and jowl surface area after volumetric radiofrequency treatments to half of the face. [2004.06]
BACKGROUND: Radiofrequency application through a proprietary device has recently been used for facial tissue tightening. Uniform volumetric heating of the dermis is created by passage of electrical current, while protection of the epidermis is maintained by concurrent cryogen cooling. OBJECTIVE: To objectively quantify the effectiveness of volumetric radiofrequency application on the face, we treated 10 patients on the left side of the face with radiofrequency and evaluated the changes in brow position, superior palpebral crease, angle of the eyebrow, and jowl surface area... CONCLUSIONS: The application of radiofrequency to the face provides quantifiable changes. The brow along the midpupillary line is elevated to a greater degree than the lateral brow. This is consistent with acute angle changes seen in the eyebrow. Improvements in the lower part of the face with radiofrequency application can be quantified by demonstrating a decrease jowl surface. Moreover, these measurement techniques can be useful tools for evaluating other treatment parameters with radiofrequency application.
Matrix metalloproteinase-1 production observed after solar-simulated radiation exposure is assumed by dermal fibroblasts but involves a paracrine activation through epidermal keratinocytes. [2004.06]
Chronic exposure of human skin to solar UV radiation leads to serious dermal damages, a hallmark of photoaging. In vivo, acute UV radiation has been shown previously to induce various matrix-degrading proteases... Altogether, these data show that MMP-1 production observed after SSR exposure involved the release of soluble epidermal factors, which could modulate its production by dermal fibroblasts.
Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. [2004.06]
Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging...
[Evaluation of a compound with dan-shen root and azone for scar treatment] [2004.05]
OBJECTIVE: To evaluate the effect of the compound of Dan-shen root and azone for scar treatment... CONCLUSION: The Dan-shen root with azone could be easier to permeate the skin and more effective to treat the hypertrophic scar.
Using intense pulsed light for cosmetic purposes: our experience. [2004.05]
The authors' experience using intense pulsed light for skin rejuvenation is summarized and analyzed with regard to its efficacy, safety, and complications. Rejuvenation using intense pulsed light was performed on 59 patients over a 6-month period (January of 2002 to July of 2002); these patients served as the study group.
Ultrasound imaging demonstration of the improvement of non-ablative laser remodeling by concomitant daily topical application of 0.05% retinaldehyde. [2004.05]
BACKGROUND: Retinaldehyde has been proven to be effective in the reduction of facial wrinkles. It has also demonstrated its usefulness when used before and after laser skin resurfacing. OBJECTIVE: A monocentric, comparative, randomized, double-blind study was performed to evaluate the efficacy of retinaldehyde versus excipient in combination with non-ablative laser remodeling treatment... CONCLUSION: When considering the reduced number of patients in each group, the statistical analysis demonstrates an evident advantage of using retinaldehyde versus excipient. This study demonstrates that irradiation with a 1540 nm Er:glass laser can be potentiated with concomitant daily topical application of 0.05% retinaldehyde.
Tretinoin peels versus glycolic acid peels in the treatment of Melasma in dark-skinned patients. [2004.05]
BACKGROUND: Chemical peels have become a popular method for treating melasma. Although daily topical 0.05 and 0.1% tretinoin have been used for melasma, the therapy takes at least 4 to 6 months to produce clinically significant lightening. In a recent trial, 1% tretinoin peel has shown good clinical and histologic results after biweekly applications in 2.5 weeks only in the treatment of melasma. OBJECTIVE: Because there is a paucity of studies evaluating the efficacy and safety of 1% tretinoin peel in the treatment of melasma in dark-skinned Asian population, we conducted a pilot study to evaluate the efficacy and side effects of this potentially new peeling agent versus a standard peeling agent, 70% glycolic acid, in the treatment of melasma in Indian women... CONCLUSIONS: It was concluded from the present trial that serial 1% tretinoin peel is a well tolerated and as effective a therapy for melasma in dark-skinned individuals as a standard and well-tried chemical peel, 70% glycolic acid, although larger trials over longer periods may be necessary to substantiate such findings.
The "R.A.R.E." technique (reverse and repositioning effect): the renaissance of the aging face and neck. [2004.05]
Considering the fixed points of the face (Fig. 1), and in light of the fact that gravity is one of the main factors involved in aging, a new alternative concept in cosmetic surgery is discussed in this paper...
Tazarotene: therapeutic strategies in the treatment of psoriasis, acne and photoaging. [2004.05]
Tazarotene is a member of the new generation of receptor-selective, synthetic retinoids for the topical treatment of mild to moderate plaque psoriasis, acne vulgaris and photoaging. Though they are effective in monotherapy, clinical studies with a focus on novel combination treatments and a comparison of different agents for these skin disorders are accumulating...
Soft tissue augmentation using sculptra. [2004.05]
Sculptra (poly-L-lactic acid) as of August 2004 has been approved by the U.S...
Soft tissue augmentation using Restylane. [2004.05]
Soft tissue augmentation plays an important role in facial rejuvenation.
Rosacea: where are we now? [2004.05]
Advances continue to be made in the classification and treatment of rosacea, a chronic dermatologic syndrome. A new empiric classification system identifies 4 rosacea subtypes (erythematotelangiectatic, papulopustular, phymatous, and ocular) that may aid in more precise diagnosis... With this expanded armamentarium of medical and light-based therapies, clinicians can now implement a multifaceted approach to treatment, crafting new treatment combinations to address the unique and evolving features of rosacea in each individual patient.
Remission of rosacea induced by reduction of gut transit time. [2004.05]
Rosacea is a chronic disorder characterized by hypersensitivity of the facial vasculature, presenting with intense flushing eventually leading to chronic erythema and telangiectasia. Although the precise aetiology of rosacea is not known, numerous associations with inflammatory gastrointestinal tract disorders have been reported...
Radiance. [2004.05]
New injectable agents are expanding the role of fillers in facial soft tissue augmentation. Radiance FN (fine needle) is a new injectable filler composed of calcium hydroxylapatite (CaHA) microspheres suspended in an aqueous gel carrier...
Penetration and metabolism of topical retinoids in ex vivo organ-cultured full-thickness human skin explants. [2004.05]
The human epidermis contains endogenous retinoids [retinol (vitamin A) and retinyl esters] and carotenoids (mostly beta-carotene). Previous studies in the mouse have shown that the enzymes involved in retinoid metabolism are present in the epidermis... When applying this concept to our results obtained in Franz cells with human skin, we conclude that topical retinol and retinal load human skin with both storage and functional vitamin A.
Nonablative laser treatment of wrinkles: meeting the objective? Assessment by 25 dermatologists. [2004.05]
BACKGROUND: Established skin resurfacing methods causing superficial wounds and extended recovery times have become less popular since the introduction of nonablative lasers. OBJECTIVES: To evaluate the clinical efficacy of a nonablative 1450-nm diode laser system... CONCLUSIONS: Nonablative laser treatment subjectively satisfies patients but does not convince objective judgement.
Laser hair removal. [2004.05]
The evolution of new technologies has helped to improve the clinical efficacy of laser hair removal and increase understanding of hair biology and phototrichoregulatory interactions. Long-term hair removal is now a realistic goal in the majority of individuals.Although the optimal schedule for repeat treatments is not known, most laser surgeons report treatments at 4- to 8-week intervals or at the first signs of regrowing hairs.Newer radiofrequency technologies might address the issue of white and light blond hair phenotypes;however, their exact role in the laser hair removal armamentarium remains to be further elucidated by future studies..
Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin. [2004.05]
Mutations of mitochondrial (mt) DNA such as the 4977 base-pair large-scale deletion, also called common deletion, are increased in photoaged skin. Direct evidence for their induction by chronic exposure to ultraviolet (UV) radiation in vivo in human skin has remained elusive however...
Hylaform: a new hyaluronic acid filler. [2004.05]
Hylaform is a new facial filler composed of hyaluronic acid.It works particularly well in wrinkles, grooves, and thin lips deflated from aging changes.
Histological hair removal study by ruby or alexandrite laser with comparative study on the effects of wavelength and fluence. [2004.05]
BACKGROUND: Several different laser systems are currently used to remove unwanted hairs. In this study, we studied follicular changes following hair removal with ruby or alexandrite lasers at different fluences... CONCLUSION: In this study, the histological changes following treatment with a ruby or an alexandrite laser at the same fluence are similar.
Hair removal using a combination of conducted radiofrequency and optical energies--an 18-month follow-up. [2004.05]
OBJECTIVE: Multiple lasers and intense pulsed light sources have been shown to provide long-term hair removal; however, the management of all dark skin phenotypes and light-colored hair remains problematic. The present study examined the long-term photoepilatory effect of a combined intense pulsed light (IPL) (680-980 nm)/radiofrequency (RF) (10-30 J/cm3) light source and its efficiency for the treatment of multiple skin phenotypes and varied hair colors... CONCLUSION: The combined IPL (680-980 nm)/RF light source with contact cooling is a safe and effective method of long-term hair reduction in patients of diversified skin types and varied hair colors and is associated with excellent patient safety.
Double-blind, randomized, vehicle-controlled clinical trial of once-daily benzoyl peroxide/clindamycin topical gel in the treatment of patients with moderate to severe rosacea. [2004.05]
CONCLUSION: A once-daily topical application of a combination of 5% benzoyl peroxide and 1% clindamycin is effective and well tolerated in patients with moderate to severe rosacea.
Cymetra. [2004.05]
Soft tissue replacement using a filler as a temporary scaffold to encourage revascularization and tissue in growth is an exciting concept. Sheets of acellular human dermal matrix, called Alloderm (Lifecell Corp, Branchburg, NJ), have been shown to do just that.This article reviews the manufacturing, tissue interaction, clinical applications, and anticipated clinical results.
CosmoDerm/CosmoPlast (human bioengineered collagen) for the aging face. [2004.05]
Type 1 collagen loss in the dermis is one of the primary causes of wrinkles seen in aged skin. Dermal fillers using type 1 collagen derived from bioengineered skin are now being used to treat facial wrinkles...
Botox and collagen for glabellar furrows: advantages of combination therapy. [2004.05]
Plastic surgeons frequently administer botulinum toxin A (Botox) or collagen as monotherapy to treat glabellar furrows... By simultaneously addressing the static and dynamic aspects of glabellar furrows, dual therapy provides optimal treatment of this problem.
Advanta implants. [2004.05]
Advanta is a new expanded polytetrafluoroethylene implant with dual porosity that can be used to enhance facial features... The implants feel soft and natural and the complication rate is low.
[The clinical observation of treating acne vulgaris with "xiao cuo fang"] [2004.04]
OBJECTIVE: To observe the clinical curative effect of Chinese medicine "xiao cuo fang" combined with adapalene gel in the treatment of acne vulgaris... CONCLUSION: The curative effect of "xiao cuo fang" combined with adapalene gel in the treatment of acne vulgaris is precise, and the side effects are small.
Treatment of human Demodex folliculorum by camphor oil and metronidazole. [2004.04]
A total of 15 females suffering from erythematotelangiectatic rosacea and 12 females free from other dermatological lesions were selected. Demodex folliculorum infestation density in both patients and control were evaluated by non-invasive skin surface biopsies... The results were very successful with no clinical side effects.
Tazarotene 0.1% cream for the treatment of photodamage. [2004.04]
Tazarotene (Tazorac, Allergan) has been shown to be effective in reducing the effects of photoaging in short term studies. To determine its effectiveness in the longer term, a 24-week multicenter, double-blind, randomized, vehicle controlled intervention study of 562 patients with facial photodamage was carried out followed by a 28-week open label extension...
Resurfacing of different types of facial acne scar with short-pulsed, variable-pulsed, and dual-mode Er:YAG laser. [2004.04]
BACKGROUND: Laser skin resurfacing has become a popular therapeutic modality for the correction of acne scars, but it is not always effective in all types of acne scars. OBJECTIVE: To evaluate the clinical effects of resurfacing with the short-pulsed Er:YAG laser, the variable-pulsed Er:YAG laser, and the dual-mode Er:YAG laser for each type of facial acne scars... CONCLUSION: Shallow boxcar and ice-pick scars can be treated successfully using any types of Er:YAG laser. In cases of rolling and deep boxcar scars, however, Er:YAG laser with a long-pulse duration for a thermal effect is needed for successful treatment.
Improvement of neck and cheek laxity with a nonablative radiofrequency device: a lifting experience. [2004.04]
OBJECTIVE: Laxity of cheek and neck skin is a common cosmetic complaint of patients as they age. Improvement of skin laxity can be difficult to achieve without invasive surgical lifting procedures. The object of this study was to evaluate the safety and efficacy of a novel nonablative radiofrequency device in the treatment of cheek and neck laxity... CONCLUSIONS: Noninvasive radiofrequency bulk dermal heating of skin can achieve safe and effective tissue tightening of the cheeks and neck. Although tightening continued to be evident 6 months after a single treatment, the longevity of clinical results has yet to be determined.
Focal trichloroacetic acid peel method for benign pigmented lesions in dark-skinned patients. [2004.04]
BACKGROUND: Benign pigmented lesions, including seborrheic keratosis, solar lentigines, melasma, and freckles, are common disorders, and various treatment modalities have been tried. We suggest a technique consisting of focal trichloroacetic acid (TCA) peel applied by pressing firmly onto the focal lesions. OBJECTIVE: To evaluate the clinical effects of focal TCA peel on pigmented lesions in dark-skinned patients... CONCLUSION: The focal TCA peel method presented in this study is a safe and effective modality for the treatment of benign pigmented lesions with no significant complications.
Dilution, storage, and electromyographic guidance in the use of botulinum toxins. [2004.04]
Botulinim toxin A (BTX-A) is available commercially in two formulations: Botox (Allergan, Inc.
Dermal echogenicity: a biological indicator of individual cumulative UVR exposure? [2004.04]
Dermal alterations due to chronic UVR exposure may influence dermal ultrasound echogenicity, and a subepidermal low-echogenic band has been proposed as a marker of photoaging. The aim of this study was to determine whether dermal echogenicity could be used as a biological UVR dosimeter...
Comparison of botulinum toxins A and B in the treatment of facial rhytides. [2004.04]
Facial rhytides of the upper one third of the face are common aesthetic concerns, and are caused principally by overactivity of the underlying facial musculature. Botulinum toxin, which acts by causing flaccid paralysis of facial mimetic muscles, has become a treatment of choice for the management of these hyperfunctional facial lines...
Comparing 18- versus 12-mm spot size in hair removal using a gentlease 755-nm alexandrite laser. [2004.04]
BACKGROUND: Laser epilation is based on the principle of selective photothermolysis, absorption of laser energy by the target chromophore melanin. It is claimed that larger spot sizes may be more effective for hair removal at identical fluences. OBJECTIVE: To compare the efficacy of 18- vs. 12-mm spot size in hair removal using a Gentlelase Alexandrite laser from Candela Corporation (Boston, MA)... CONCLUSION: Our results indicate that a larger spot size appears to be more effective for laser assisted hair removal.
Botulinum toxin A in the mid and lower face and neck. [2004.04]
Botulinum toxins have been smoothing hyperkinetic lines in the upper face for over 15 years. More recently, their use has widened to include applications in the mid and lower face and neck to smooth, shape, and sculpt, blurring the line between science and art.
Two-plane injection of botulinum exotoxin A in glabellar frown lines. [2004.03]
Botulinum exotoxin A has been used for the treatment of glabellar frown lines... It is concluded that botulinum exotoxin is more effective when it is applied in two planes superficially and deep so that the anatomic course of the corrugator supercilii and the depressor supercilii muscles are followed.
Topical retinoid and antibiotic combination therapy for acne management. [2004.03]
The agents most commonly used in combination for the management of acne include topical retinoids and antibiotics. Topical retinoids normalize desquamation of the follicular epithelium, whereas antibiotics inhibit the growth of P... The rationale of utilizing topical retinoids with antibiotics will be highlighted, particularly in relation to improved tolerance and reduced irritation.
The effect of full-face broadband light treatments alone and in combination with bilateral crow's feet Botulinum toxin type A chemodenervation. [2004.03]
BACKGROUND: Broadband light (BBL; Intense Pulsed Light; Lumenis Ltd., Yokneam, Israel) is a powerful, nonablative, light-based technology that targets melanin and hemoglobin and stimulates the formation of collagen and elastin. Botulinum toxin type A (BTX-A; BOTOX; Allergan Inc., Irvine, CA) treatment of the lateral periocular region relaxes the vertical fibers of the orbicularis oculi and results in softening of the lateral orbital crow's feet rhytides and widening of the palpebral aperture. OBJECTIVE: To compare the effects of full-face BBL in combination with BTX-A and BBL alone in female subjects with Fitzpatrick I-III skin types, Glogau II-III rhytides, and significant associated facial lentigines and telangiectasia... CONCLUSIONS: The patients in this study benefited from both treatments. Although BBL led to a remarkable improvement in full-face telangiectasias, lentigines, and skin texture, the improvement increased in all categories with combination therapy. In addition, an added improvement in the full-face aesthetic with both BTX-A and BBL therapy combined was obvious. These results suggest that both treatments--although evidently complementary--may also act synergistically to produce optimal clinical effects, revolutionizing the treatment of facial aging.
Rationale for the use of topical corticosteroids in melasma. [2004.03]
Corticosteroids have been combined with other agents in the treatment of melasma for years... When used in combination with tretinoin and hydroquinone in the treatment of melasma, fluocinolone acetonide 0.01% suppresses biosynthetic and secretory functions of melanocytes, and thus melanin production, leading to early response in melasma, synergy among the three agents, and no significant side effects over an 8-week period.
Melasma: a review. [2004.03]
OBJECTIVE: To better understand melasma, a review of its etiologic factors, classification, pathogenesis, and treatment was undertaken... CONCLUSION: Melasma is a common skin disorder. Although melasma has been studied, its pathogenesis remains largely unknown and its treatment is still met with difficulty. Randomized controlled trials involving larger numbers of patients and comparing treatments, as well as studying combination therapies, would be beneficial.
Endoscopic-assisted face lift: review of 200 cases. [2004.03]
The use of endoscopic techniques in facial esthetic surgery has gained increasing popularity in the last decade... In this group the endoscope was used as a tool for better magnification and illumination.
Efficacy of hydroquinone (2%) versus tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma. [2004.03]
BACKGROUND AND OBJECTIVES: In recent years, chemical peels have become increasingly popular in the treatment of melasma. However, postpeel hyperpigmentation is a frequently encountered side effect, especially in dark-skinned individuals. The role of priming agents in preventing this complication has not been adequately evaluated. Hence, we studied the effect of hydroquinone versus tretinoin as priming agents in minimizing the incidence of this side effect in a double-blind, randomized clinical trial of 50 patients with melasma... CONCLUSIONS: Hydroquinone is superior to tretinoin as a priming agent in maintaining the results achieved with peels and in decreasing the incidence of postpeel reactive hyperpigmentation.
Delivery of vitamin E to the skin by a novel liquid skin cleanser: comparison of topical versus oral supplementation. [2004.03]
Topical supplementation represents an attractive approach to mitigate environmentally induced deficiencies of skin vitamin E (alpha-tocopherol). We report here the impact of natural sunlight on stratum corneum (SC) vitamin E and also compare the effectiveness of dietary supplementation to topical application as a way to increase vitamin E in the superficial layers of the SC...
A systemic type I 5 alpha-reductase inhibitor is ineffective in the treatment of acne vulgaris. [2004.03]
Excessive sebum production is a central aspect of the pathophysiology of acne vulgaris... These results indicate the need for further work at the molecular level to better understand the action of androgens on sebaceous gland function.
Use of the KTP laser in the treatment of rosacea and solar lentigines. [2004.02]
Numerous techniques have evolved in facial plastic surgery to treat rosacea and solar lentigines... A review of both conditions and other treatment options is discussed.
Treatment of inflammatory facial acne vulgaris with the 1450-nm diode laser: a pilot study. [2004.02]
BACKGROUND: The 1450-nm diode laser has been found to damage sebaceous glands selectively and to be effective for the treatment of inflammatory acne on the back. OBJECTIVE: To evaluate the efficacy and safety of the 1450-nm diode laser in the treatment of inflammatory facial acne vulgaris... CONCLUSION: This is the first published report documenting the safety and efficacy of laser treatment for inflammatory facial acne. In our study, clinical improvement was seen in all patients and was generally dramatic, even in those refractory to previous treatment with oral isotretinoin. Topical anesthetics should be used to minimize pain associated with treatment.
Therapeutic potential of azithromycin in rosacea. [2004.02]
BACKGROUND: Systemic antibiotics currently used in the treatment of rosacea are sometimes associated with uncomfortable side-effects. Therefore, a need for an effective agent with few side-effects and good patient compliance exists. Azithromycin, a macrolide antibiotic with prolonged mode of action, has recently been found to be an effective alternative in the treatment of inflammatory acne. We planned a study to evaluate the efficacy and safety of azithromycin in rosacea... CONCLUSION: Azithromycin is a promising agent in the treatment of rosacea with its few side-effects and good patient compliance.
The use of polyhydroxy acids (PHAs) in photoaged skin. [2004.02]
The beneficial effects of alpha-hydroxyacids (AHAs) on skin were discovered by Drs... Finally, PHA-containing products were shown to be compatible with African American, Caucasian, and Hispanic/Asian skin and provided significant improvements in photoaging in these populations.
The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging. [2004.02]
BACKGROUND: Ultraviolet (UV) radiation damages skin through a variety of mechanisms, including the generation of free radicals. Gluconolactone is a polyhydroxy acid (PHA) that is capable of chelating metals and may also function by scavenging free radicals, thereby protecting skin from some of the damaging effects of UV radiation. OBJECTIVE: This study measured the ability of gluconolactone to protect against UV radiation-induced damage... CONCLUSIONS: These results demonstrate the ability of the PHA gluconolactone to protect against UV radiation-induced elastin promoter activation. In addition, in vivo studies demonstrated that gluconolactone treatment does not result in a significant increase in sunburn cells. Further investigation of this and other PHAs is necessary to identify their potential role in preventing and repairing cutaneous photodamage.
Microcoblation: nonablative skin rejuvenation. [2004.02]
Microcoblation is the application of a controlled high-energy plasma field to intact aging skin. The treatment is nonablative and yields predictable, reversible histological changes in the epidermis, which result in skin rejuvenation... Although the mechanism of action is different, patient satisfaction with microcoblation compares very favorably with microdermabrasion, the traditional method of superficial skin rejuvenation.
Laser surgery: an approach to the pediatric patient. [2004.02]
Revolutionary advances in laser research and technology have led to expanded dermatologic laser applications. With the wide range of lasers now available, a large spectrum of skin conditions in the pediatric population can be successfully treated or, in some cases, completely eradicated.Learning objective: At the conclusion of this learning activity, participants should be familiar with the mechanism of laser technology, current trends in the use of lasers for skin lesions in the pediatric population, and the issues specific to treating a patient with laser surgery.
Comparison of a 1450-nm diode laser and a 1320-nm Nd:YAG laser in the treatment of atrophic facial scars: a prospective clinical and histologic study. [2004.02]
BACKGROUND: Atrophic scar revision techniques, although numerous, have been hampered by inadequate clinical responses and prolonged postoperative recovery periods. Nonablative laser treatment has been shown to effect significant dermal collagen remodeling with minimal posttreatment sequelae. Although many studies have been published regarding the effectiveness of these nonablative lasers on rhytides, there are limited data demonstrating their specific effects on atrophic scars. OBJECTIVE: To evaluate and compare the efficacy and safety of long-pulsed 1320-nm Nd:YAG and 1450-nm diode lasers in the treatment of atrophic facial scarring... CONCLUSIONS: Nonablative long-pulsed 1320-nm Nd:YAG and 1450-nm diode lasers each offer clinical improvement for patients with atrophic scarring without significant side effects or complications. The 1450-nm diode laser showed greater clinical scar response at the parameters studied. The use of nonablative laser systems is a good treatment alternative for patients with atrophic scarring who are unable or unwilling to endure the prolonged postoperative recovery process associated with ablative laser skin resurfacing procedures.
Chemical peels. [2004.02]
With so many new peel preparations on the market today, the dermatologist must ask himself basic questions concerning the products... Only then will we truly know the effectiveness of the agents we are using for exfoliating and resurfacing.
Alpha-hydroxyacid chemical peeling agents: case studies and rationale for safe and effective use. [2004.02]
Chemical peeling is an in-office procedure that involves the application of a chemical agent to the skin to induce controlled destruction or exfoliation of old skin and stimulation of new epidermal growth with more evenly distributed melanin. When peel agents reach the dermal layer, important wound-healing activities occur that cause skin remodeling and skin smoothing, both antiaging benefits.
A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen. [2004.02]
There have been numerous clinical studies conducted to evaluate the beneficial effects of the polyhydroxy acids (PHAs) in skincare. Although there is significant evidence that PHAs provide antiaging effects to skin, a direct comparison between alpha-hydroxyacids (AHAs) and PHAs for these effects has not been conducted...
The role of topical metronidazole in the treatment of rosacea. [2004.01]
Many topical and oral pharmacologic agents have shown well-tolerated efficacy for the treatment of rosacea. Metronidazole was the first topical therapy approved for rosacea and is still considered the foundation therapy by many researchers and dermatologists.The efficacy and tolerability of topical metronidazole in combination with an oral antibiotic or as monotherapy to maintain remissions have been shown in multiple well-controlled trials.
The role of telomeres in skin aging/photoaging. [2004.01]
Recent work has substantially elucidated the mechanisms of skin aging and photoaging.These telomere-initiated responses, in combination with UV-induced damage to critical regulatory genes, lead to the familiar picture of "photoaging." These and other insights into the molecular basis for skin aging/photoaging may lead to enhanced management options.
The excimer laser in dermatology and esthetic medicine. [2004.01]
First reports about the use of the excimer laser in dermatology date back to 1997. It is seen as an improvement on conventional phototherapy and photochemotherapy because of the lower cumulative UV-dose involved, the shorter time frame required for treatment and the option of targeting individual lesions without affecting the surrounding healthy skin.
Targeted delivery of salicylic acid from acne treatment products into and through skin: role of solution and ingredient properties and relationships to irritation. [2004.01]
Salicylic acid (SA) is a beta hydroxy acid and has multifunctional uses in the treatment of various diseases in skin such as acne, psoriasis, and photoaging. One problem often cited as associated with salicylic acid is that it can be quite irritating at pH 3-4, where it exhibits the highest activity in the treatment of skin diseases.
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