Skin aging and natural photoprotection. [2004.01]
Aging of skin is a continuous process that may be enhanced by sun exposure... The minimal erythema dose is thus the same through life, when corrected for pigmentation or measured in areas with constitutive pigmentation.
Rosacea: a clinicopathological approach. [2004.01]
BACKGROUND: There are few reports of the histological changes in rosacea, and little attempt has been made to correlate such changes with clinical findings. In the present study, we describe in detail the histopathological features of rosacea in a large number of patients and simultaneously investigate the aetiopathogenesis of the disease based on the comparative assessment of epidemiological, clinical and histological findings... CONCLUSION: Rosacea seems to be a reaction pattern to which a variety of pathogenetic routes may lead.
Pyruvic acid peels for the treatment of photoaging. [2004.01]
BACKGROUND: Pyruvic acid (CH3-CO-COOH), an alpha-keto-acid, has been recently used as a medium chemical peeling agent in subjects with inflammatory acne, moderate acne scars, greasy skin, actinic keratosis, and warts. OBJECTIVE: The aim of our study was to evaluate the efficacy and tolerability of 50% pyruvic acid on moderately photodamaged facial skin... CONCLUSION: Thus, 50% pyruvic acid peeling can be proposed as a safe and efficient treatment for moderate facial skin aging.
Pulsed dye laser and non-ablative wrinkle reduction. [2004.01]
BACKGROUND AND OBJECTIVES: Non-ablative wrinkle reduction is currently an issue, which is being widely discussed in the literature and at academic meetings worldwide. We present the findings of our randomized within patient controlled clinical trial into periorbital wrinkle reduction with a 595 nm pulsed dye laser... CONCLUSIONS: The 595 nm pulsed dye laser set at 0.5 millisecond pulse width is not an effective means of achieving sub-purpuric non-ablative periorbital wrinkle reduction. Copyright 2004 Wiley-Liss, Inc.
Photorejuvenation with intense pulsed light: results of a multi-center study. [2004.01]
This multi-center study evaluating the role of Intense Pulsed Light (IPL) in the non-ablative rejuvenation of Type I and Type II photoaged skin study was conducted in order to evaluate the clinical efficacy and safety of using IPL in treating clinical indications associated with photoaged skin...
Mechanism-based selection of pharmacologic agents for rosacea. [2004.01]
All effective agents used to treat rosacea have a common mechanism of action: anti-inflammatory effects. Concomitant with this, many of these agents also show antioxidant effects.
Long-pulsed 1064-nm Nd:YAG laser-assisted hair removal in all skin types. [2004.01]
BACKGROUND: Although there are several different laser systems available for the reduction of unwanted hair, no single system has been shown to be superior in providing safe and effective hair removal in every skin type. The purpose of this study was to evaluate the safety and efficacy of a high-energy, long-pulsed, 1064-nm Nd:YAG laser with a contact cooling device for hair removal in skin phototypes I-VI... CONCLUSION: The long-pulsed 1064-nm Nd:YAG laser with contact cooling is a safe and effective method of hair reduction in patients of all skin types. Side effects were limited and transient.
Interventions for rosacea. [2004.01]
CONCLUSIONS: The quality of studies evaluating rosacea treatments was generally poor. There is evidence that topical metronidazole and azelaic acid cream have a therapeutic effect. There is some evidence that oral metronidazole and tetracycline are effective.There is insufficient evidence concerning the effectiveness of other treatments. As many of these treatments are used for rosacea, good RCTs are urgently needed.
Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. [2004.01]
BACKGROUND AND OBJECTIVES: We introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin... CONCLUSIONS: FP is a new concept for skin restoration treatment. Safety and efficacy were demonstrated with a prototype device. Further clinical studies are necessary to refine the optimum parameters and to explore further dermatological applications. Copyright 2004 Wiley-Liss, Inc.
Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. [2004.01]
The combination of sodium sulfacetamide and sulfur is unique in the rosacea armamentarium because of its dual use as topical therapy and therapeutic cleanser. Several formulations of sulfacetamide 10% and sulfur 5% are now available as topical lotions and cleansers.The sulfacetamide/sulfur cleansers serve as adjunctive therapy by providing additive effects to other topical and oral therapies for rosacea with favorable tolerability and cosmetic appeal.
Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage. [2004.01]
BACKGROUND: Photorejuvenation involves the use of a light source or laser in reversing the signs of aging. The Intense Pulsed Light (IPL) has demonstrated effectiveness in treating signs of photodamage. Photodynamic therapy is a relatively new and promising treatment for actinic keratoses. OBJECTIVE: To determine the effectiveness of ALA-IPL in treating actinic keratoses as well as reversing the signs of aging... CONCLUSIONS: ALA-IPL treatment is effective in treating both actinic keratoses and signs of photodamage. In this study, we achieved significant improvement after just one treatment. ALA-IPL is a safe, effective way to treat both actinic keratoses and photodamage with little down time.
Deep-plane face-lift vs superficial musculoaponeurotic system plication face-lift: a comparative study. [2004.01]
OBJECTIVE: To evaluate deep-plane face-lift vs superficial musculoaponeurotic system (SMAS) plication face-lift in correcting the melolabial fold, jowl, and cheek areas of the face in short-term follow-up... CONCLUSION: Deep-plane face-lift does not seem to offer superior results over SMAS plication face-lift in patients younger than 70 years.
Cosmetic uses of botulinum toxins for lower aspects of the face and neck. [2004.01]
The ability of botulinum toxin A (BTX-A) to improve the appearance of facial lines was first reported among patients who had been receiving injections for facial dystonias or surgical procedures. Since that time, there has been very extensive use of this treatment for relaxation of a wide variety of facial muscles and also for platysmal lines of the neck...
Contraindications and complications with the use of botulinum toxin. [2004.01]
Cosmetic use of BTX has skyrocketed in recent years, especially since the approval of BTX-A for treatment of glabellar lines.It is important for the injecting physician to be familiar with these potential complications, even though the use of BTX has been safe and generally well tolerated, because it will lead to even greater success with the use of BTX.
Clinical evaluation of roxithromycin: a double-blind, placebo-controlled and crossover trial in patients with acne vulgaris. [2004.01]
We clinically evaluated roxithromycin (ROM) in a double blind, placebo-controlled, and crossover trial in patients with inflammatory acne. Patients with inflammatory acne who were attending our outpatient clinic for treatment and who had not received topical or systemic treatment for the previous month were enrolled in this study.
Azelaic acid 15% gel: in the treatment of papulopustular rosacea. [2004.01]
Azelaic acid is a naturally occurring, straight-chain dicarboxylic acid which is effective in the treatment of rosacea, presumably on account of its anti-inflammatory properties. In randomized, double-blind, multicenter studies involving patients with moderate papulopustular facial rosacea, twice-daily topical application of azelaic acid 15% gel to the face was significantly more effective than twice-daily administration of either its vehicle (two studies) or metronidazole 0.75% gel (one study) in reducing inflammatory lesion counts and erythema severity...
Antioxidant activity of topically applied lycopene. [2004.01]
BACKGROUND: Ultraviolet (UV) rays cause depletion of the antioxidant substances contained in the epidermis. This is the rationale for the use of topical antioxidant substances... CONCLUSIONS: Lycopene has suitable characteristics to be used successfully in the prevention of cutaneous damage by free radicals. Its antioxidant ability is probably due to its high reductive power.
A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. [2004.01]
BACKGROUND: There is no completely satisfactory treatment for multiple actinic keratoses (AKs). OBJECTIVE: To evaluate the efficacy of short incubation, broad-area application of delta-aminolevulinic acid followed by exposure to activating light-photodynamic therapy (delta-ALA/PDT) for treatment of AKs and background photodamage. The benefit of pretreatment with 40% urea cream to enhance penetration and the use of topical 3% lidocaine hydrochloride to decrease discomfort were also evaluated... CONCLUSIONS: This delta-ALA/PDT protocol is safe and effective for AK treatment as well as for improving photodamage. Further studies with a larger cohort, longer follow-up, and histologic confirmation of the clinical data would be of value.
A study on patients treated with polyacrylamide hydrogel injection for facial corrections. [2004.01]
Polyacrylamide hydrogel (PAAG) has been used as a tissue filler in facial corrective surgery and for breast augmentation in Kiev, Ukraine, for more than 10 years with reportedly very good results. These results, however, have not been published in peer-reviewed journals... Currently, the product (Aquamid) is being studied in several prospective clinical trials, one of which is completed and in the process of preparation for publication.
Selective electro-thermolysis in aesthetic medicine: a review. [2004]
The use of radiofrequency (RF) for selective electro-thermolysis has been found to produce a highly efficient thermal effect on biological tissue.This article discusses the properties of electrical current in medicine and reviews the studies to date that have evaluated RF energy for dermatological applications.
Acne in ethnic skin: special considerations for therapy. [2004]
Acne vulgaris occurs in people of all ethnicities and races. Although the pathophysiology and treatment options are similar in all skin phototypes, darker-skinned patients have higher incidence rates of two sequelae of acne: postinflammatory hyperpigmentation and keloidal scarring...
The use of lasers and intense pulsed light sources for the treatment of acquired pigmentary lesions in Asians. [2003.12]
Asians are prone to the development of lentigines as a result of photoageing.
Safety and efficacy of 4% hydroquinone combined with 10% glycolic acid, antioxidants, and sunscreen in the treatment of melasma. [2003.12]
BACKGROUND: Melasma, also known as mask of pregnancy, is a common, acquired hypermelanosis seen in women with Fitzpatrick skin types II-V, and is often recalcitrant to treatment with depigmentation agents. Glycolic acid has been added to hydroquinone formulations in the past to enhance their depigmentation effects, but may cause irritation, leading to postinflammatory hyperpigmentation. AIM: To assess the safety and efficacy of a cream containing 4% hydroquinone, 10% buffered glycolic acid, vitamins C and E, and sunscreen (Glyquin, ICN Pharmaceuticals, Costa Mesa, USA) vs. a cream containing sunscreen alone in the depigmentation of epidermal melasma of the face... CONCLUSIONS: A cream containing 4% hydroquinone, 10% buffered glycolic acid, vitamins C and E, and sunscreen is safe and effective in the treatment of melasma.
Permanent hair removal with a diode-pumped Nd:YAG laser: a pilot study using the direct insertion method. [2003.12]
CONCLUSION: The direct insertion optical method (DIOM), delivering laser energy directly to the hair bulb through an optical needle, has proven to be effective and achieves permanent hair removal in 60% of volunteers without medical complications.
Hair removal with a combined light/heat-based photo-epilation system: a 6-month follow-up. [2003.12]
BACKGROUND: A variety of lasers and light sources have been used for hair removal. A novel flashlamp-based device, with a mechanism of action mixing a combination of light and heat, has recently become available. OBJECTIVE: To assess the efficacy, side effects and long-term results of this new light/heat-based system for photo-epilation... CONCLUSION: The present study demonstrates that this device is safe and effective for hair removal with a long-term effect.
Hair reduction: 48 months of experience with 800nm diode laser. [2003.12]
BACKGROUND: The goal of hair removal methods has always been permanent or at least long-term epilation. Laser technology and the axiom of selective photothermolysis allowed a new approach to this subject. OBJECTIVE: The aim of this retrospective study was to determine the long-term efficacy of a solid state, 800nm pulsed near infrared diode laser system for the reduction of pigmented hair, and extending habitual hair plucking intervals... CONCLUSION: 800-nm diode laser assisted hair removal represents a safe and effective treatment option for the reduction of pigmented hair.
Granulomatous foreign body reaction against hyaluronic acid: report of a case after lip augmentation. [2003.12]
CONCLUSION: To our knowledge, this is the third case of granulomatous body reaction against this substance, which was allegedly inert in humans. Although rare, this reaction can have important aesthetic implications, and the patients should be informed about their risks.
Efficacy of long- and short pulse alexandrite lasers compared with an intense pulsed light source for epilation: a study on 532 sites in 389 patients. [2003.12]
BACKGROUND: Undesirable hair growth presents a significant problem for many patients, and photoepilation has become a very popular procedure in aesthetic and cosmetic practice. Among the systems used are the long- and short-pulsed alexandrite lasers (LP-Alex, SP-Alex) and intense pulsed light (IPL) sources. The present study retrospectively examined the outcome of these systems from the viewpoint of efficacy and side effects... CONCLUSIONS: There was no statistically significant difference between the LP-, SP-Alex and IPL photoepilation with regard to efficacy. Transient side effects were highest with the LP-Alex, and least with the IPL system. In the LP-Alex treated face and neck sites, 3.1% had hair induction in the borders of the treated areas.
Effect of a fucose-rich polysaccharide preparation on the age-dependent evolution of the skin surface micro-relief. [2003.12]
It was demonstrated previously that the evaluation of the microdepressionary skin surface relief by semi-automated computerised morphometry enables the determination of several of its geometrical parameters, such as, the average number of polygons in a given microscopic field, and/or the average surface of the polygons...
Cumulative irritancy potential of adapalene cream 0.1% compared with adapalene gel 0.1% and several tretinoin formulations. [2003.12]
Thirty-one subjects (8 males and 23 females; mean age, 49.8 years) were enrolled in a single-center study to assess the irritancy potential of adapalene (Differin cream 0.1% and Differin gel 0.1%) and tretinoin (Avita cream 0.025%, Retin-A cream 0.025%, Retin-A cream 0.05%, Retin-A Micro gel 0.1%, and generic cream 0.025%) as compared with white petrolatum when applied under occlusive conditions...
Clinical observation in 86 cases of acne vulgaris treated with Compound Oldenlandis Mixture. [2003.12]
86 cases of acne vulgaris were treated with Fu Fang She She Cao He Ji ([symbol: see text] Compound Oldenlandis Mixture), with the other 34 cases treated with Dang Gui Ku Shen Wan ([symbol: see text] Pills Prepared from Chinese Angelica and Flavescent Sophora Root) as the controls, to observe the therapeutic effect of the former.
Vitamin A exerts a photoprotective action in skin by absorbing ultraviolet B radiation. [2003.11]
Retinyl esters, a storage form of vitamin A, concentrate in the epidermis, and absorb ultraviolet radiation with a maximum at 325 nm. We wondered whether these absorbing properties of retinyl esters might have a biologically relevant filter activity... These results demonstrate that epidermal retinyl esters have a biologically relevant filter activity and suggest, besides their pleomorphic biologic actions, a new role for vitamin A that concentrates in the epidermis.
Type A botulinum toxin in the upper aspect of the face. [2003.11]
The use of botulinum toxin type A (BTX-A) for facial rejuvenation was first systematically developed by Carruthers and Carruthers on the upper aspect of the face. In the early 1990s, the first studies of the cosmetic use of BTX-A were published...
The use of Botox to treat glabellar rhytids. [2003.11]
Many areas of the face benefit from Botox. The deep vertical and horizontal creases between the eyebrows or glabellar area are the best known to cosmetically improve with Botox injections.As with almost any cosmetic procedure, adequate evaluation and pre-operative assessment can lead to a good outcome and a satisfied patient.
The effect of topical tripeptide-copper complex on healing of ischemic open wounds. [2003.11]
OBJECTIVE: To evaluate the effects of topical glycyl-L-histidyl-L-lysine tripeptide-copper complex (TCC; Iamin 2% Gel; Procyte Corporation, Redmond, WA) on healing in ischemic open wounds. STUDY DESIGN: Experimental study. SAMPLE POPULATION: Twenty-four adult male Sprague-Dawley rats... CONCLUSION: Topical TCC resulted in accelerated wound healing in ischemic open wounds. CLINICAL RELEVANCE: Topical TCC is an effective stimulant of healing of ischemic open wounds in rats and may have an application for the treatment of chronic wounds in other species. Clinical evaluation of topical TCC is warranted.
Periocular botulinum toxin. [2003.11]
Botulinum toxin type A (BOTOX, Dysport) has revolutionized treatment of wrinkles around the eyes.BOTOX is in widespread use worldwide and is currently the most popular cosmetic treatment in the United States.
Long-pulse 532-nm diode laser for nonablative facial skin rejuvenation. [2003.11]
OBJECTIVE: To evaluate the efficacy of a long-pulse 532-nm frequency doubled Nd:YAG laser for nonablative facial skin rejuvenation... CONCLUSIONS: In this preliminary study, the long-pulse 532-nm Nd:YAG laser was effective for the treatment of photoaging. The patients were pleased with the results, particularly because they were able to obtain an improvement in appearance with minimal discomfort and without any loss of time from their regular activities.
Lasers and microdermabrasion enhance and control topical delivery of vitamin C. [2003.11]
The objective of this study was to evaluate the ability of lasers and microdermabrasion, both of which are skin resurfacing modalities, to enhance and control the in vitro skin permeation and deposition of vitamin C. The topical delivery of magnesium ascorbyl phosphate, the pro-drug of vitamin C, was also examined in this study...
Incidence of side effects after laser hair removal. [2003.11]
BACKGROUND: Despite the widespread use of lasers for hair removal there are few data published on the incidence of side effects from this treatment. OBJECTIVE: The aim of this study was to generate data on a large number of patients receiving laser hair removal to obtain an accurate assessment of the incidence and type of side effects resulting from treatment... CONCLUSIONS: Laser hair removal is inherently safe. For darker Fitzpatrick skin types the long-pulsed neodymium:yttrium-aluminum-garnet laser is preferred to the ruby laser.
How to avoid complications when treating hyperdynamic folds and wrinkles. [2003.11]
Before discussing the complications that might occur in the treatment of hyperdynamic folds and wrinkles, it is important to analyze and define the correct effects and unwanted effects, or even adverse reactions, after administration of botulinum toxin (BTX) for cosmetic indications... Because this is a cosmetic treatment, not only severe adverse reactions but also patient dissatisfaction are the subjects of the following discussion.
Green tea extract suppresses the age-related increase in collagen crosslinking and fluorescent products in C57BL/6 mice. [2003.11]
Collagen crosslinking during aging in part results from Maillard reaction endproducts of glucose and oxoaldehydes. Because of the tight link between oxidative and carbonyl stress, we hypothesized that natural antioxidants and "nutriceuticals" could block collagen aging in C57BL/6 mice...
Complications of botulinum toxin A use in facial rejuvenation. [2003.11]
The esthetic application of botulinum toxin type A is a safe treatment modality; nevertheless, complications can occur as a result of patient- and physician-related factors.
Botulinum toxin in the lower one third of the face. [2003.11]
The use of botulinum toxin (BTX) in the lower one third of the face has rapidly become one of the most popular ways to rejuvenate the face, due to the effectiveness of BTX in this area and the lack of major side effects. It is recommended that physicians planning on treating patients in this area of the face first have extensive experience treating the more traditional areas, such as the forehead, glabella, or crow's feet, because the inferior one third of the face has many co-dependent and interdigitating (interrelated) muscles that are very sensitive and readily affected by minimal amounts of BTX.
Botulinum toxin A for the treatment of lateral periorbital rhytids. [2003.11]
The lateral periorbital area represents one of the earliest and most bothersome facial stigmata of aging... As more experience is gained with this toxin, as well as other Botox serotypes, continued progress is likely to occur in this area, as well as in other facial regions.
Antioxidant activity, lipid peroxidation and skin diseases. What's new. [2003.11]
Due to its interface function between the body and the environment, the skin is chronically exposed to both endogenous and environmental pro-oxidant agents, leading to the harmful generation of reactive oxygen species (ROS)... Based on these findings, the review summarises the possible correlations between antioxidant imbalance, lipid oxidative breakage and skin diseases, from both a pathological and therapeutic points of view.
Altering brow contour with botulinum toxin. [2003.11]
Brow position is determined by a dynamic interaction between depressor and elevator muscles. Botulinum toxin may be used to temporarily alter this equilibrium to result in a change in brow position... Botulinum toxin browlifting may result in an aesthetically pleasing, modest brow elevation; however, individuals who have significant brow ptosis would be better treated surgically.
A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. [2003.11]
OBJECTIVE: To compare the efficacy and safety of a novel formulation of 15% azelaic acid gel (Finacea; Berlex Laboratories, Inc, Montville, NJ) with 0.75% metronidazole gel (MetroGel; Galderma Laboratories LP, Fort Worth, Tex) as topical therapy for moderate, papulopustular facial rosacea... CONCLUSION: Use of 15% azelaic acid gel twice daily for 15 weeks demonstrated significant superiority over using 0.75% metronidazole gel in improving principal signs of rosacea (inflammatory lesions and erythema).
The role of botulinum toxin type B (Myobloc) in the treatment of hyperkinetic facial lines. [2003.10]
Botulinum toxin type B was studied for the management of hyperkinetic facial lines. It showed clinical longevity of up to 12 weeks on subjective rating scales and 8 weeks on objective rating scales.
The plastic surgeon and the prevention of facial aging process [2003.10]
The fight against aging is carried out on several levels: a healthy life, anti-aging medicine as well as fight against aging symptoms. In our days, plastic surgeons anxious to find answers to the specific demands of their patients must invest themselves in other areas, to at least, acquire the knowledge or, to enable them to practice the necessary skills to meet those needs.
The cosmetic use of botulinum toxin. [2003.10]
The approach to facial rejuvenation continues to evolve... Botulinum toxin, derived from Clostridium botulinum, is the most widely used agent; therefore, this new modality, its applications in cosmetic plastic surgery, and its applications to other areas will be discussed.
Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. [2003.10]
CONCLUSIONS: It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin.
Non-surgical radiofrequency facelift. [2003.10]
There has been considerable interest in using non-ablative methods to rejuvenate the skin... The technique was found to produce gradual tightening in most patients, and there were no adverse effects.
Herpes simplex virus prophylaxis with famciclovir in patients undergoing aesthetic facial CO2 laser resurfacing. [2003.10]
Herpes simplex virus 1 (HSV-1) reactivation may occur in patients undergoing facial carbon dioxide (CO2) laser resurfacing and can delay healing and result in severe scarring. Prophylactic oral antiviral agents are administered routinely to patients undergoing laser resurfacing to prevent postoperative HSV-1 eruptions; however, dosage and duration of treatment vary in the literature...
Full-face laser resurfacing using a supplemented topical anesthesia protocol. [2003.10]
BACKGROUND: Laser resurfacing has become a popular modality for the treatment of photodamaged skin, rhytids, and acne scarring. In many cases, this procedure is performed under general anesthesia or intravenous sedation in conjunction with nerve blocks and local infiltration.Scarring was not observed.Conclusion A supplemented topical anesthesia protocol for full-face laser resurfacing is a safe and effective alternative to traditional anesthesia strategies.
Facial volume restoration with the fat autograft muscle injection technique. [2003.10]
BACKGROUND: Fat augmentation of the aging face has been a popular cosmetic procedure for decades. Many consider fat the ideal filler because it is natural, nonallergenic, and readily available. However, longevity and symmetry of the fat graft have been unpredictable. In addition, when large volumes are injected for panfacial correction, prolonged edema for months may result. OBJECTIVE: Roger E. Amar has developed a new technique that is known as fat autograft muscle injection (F.A.M.I.) for fat augmentation. We present our experience in 100 patients who underwent this new method... CONCLUSIONS: Facial volume restoration with the F.A.M.I. technique is an artistic and systematic approach for facial volume restoration. It offers the potential for symmetric, long-term results.
Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round? [2003.10]
Solar ultraviolet radiation (UV) is a major environmental factor that dramatically alters the homeostasis of the skin as an organ by affecting the survival, proliferation and differentiation of various cutaneous cell types. The effects of UV on the skin include direct damage to DNA, apoptosis, growth arrest, and stimulation of melanogenesis...
Cutaneous effects of infrared radiation: from clinical observations to molecular response mechanisms. [2003.10]
Human skin is exposed to infrared (IR) radiation (760 nm-1 mm) from natural as well as artificial sources that are increasingly used for cosmetic or medical purposes. Epidemiological data and clinical observations, however, indicate that IR radiation cannot be considered as totally innocuous to human skin...
Comparison of trichloroacetic acid solution and cryosurgery in the treatment of solar lentigines. [2003.10]
BACKGROUND: Solar lentigines are benign keratinocytic proliferations resulting from prolonged and cumulative sun exposure. The newer photoselective lasers have become the mainstay of treatment. However, cryosurgery and trichloroacetic acid (TCA) solution are cost-effective alternatives in the treatment of solar lentigines... CONCLUSION: Cryosurgery was found to be superior to TCA 30% solution in the treatment of solar lentigines. This study demonstrates that old-fashioned treatments for solar lentigines are still excellent and cost-effective therapeutic choices.
Antioxidant activity, lipid peroxidation and skin diseases. What's new. [2003.10]
Due to its interface function between the body and the environment, the skin is chronically exposed to both endogenous and environmental pro-oxidant agents, leading to the harmful generation of reactive oxygen species (ROS)... Based on these findings, the review summarises the possible correlations between antioxidant imbalance, lipid oxidative breakage and skin diseases, from both a pathological and therapeutic points of view.
Age-dependent generation of reactive oxygen species in the skin of live hairless rats exposed to UVA light. [2003.10]
Aging proceeds by highly complicated biochemical processes, in which the involvement of the reactive oxygen species (ROS) and free radicals has been implicated. Although the relationship between UV-induced photoaging and ROS generation has been proposed, it has been difficult to establish direct proof of the generation of ROS in the skin under UV exposure...
A prospective survey of patient experiences after laser skin resurfacing: results from 2 1/2 years of follow-up. [2003.10]
BACKGROUND: Laser skin resurfacing (LSR) is a common cosmetic surgical procedure, yet there are no prospective long-term studies on patients' perceptions of their procedure. OBJECTIVE: To prospectively document patients' subjective experiences after LSR... CONCLUSIONS: Data on the evolution of patient perspective after LSR can improve patient preparation. This may help the surgeon and patient achieve shared, realistic expectations for the postoperative period and for long-term results.
Skin photoprotection by green tea: antioxidant and immunomodulatory effects. [2003.09]
Because of a characteristic aroma and health benefits, green tea is consumed worldwide as a popular beverage.
Premature skin aging by ultraviolet radiation and other environmental hazards. The molecular basis] [2003.09]
The study of the molecular basis of aging is becoming increasingly important for environmental and dermatological research. In addition to ultraviolet radiation, there are other environmental influences which play a significant role in premature aging processes of the human skin... Based on our current understanding of the molecular biological basis of the effects of environmental hazards, this overview aims at listing the most important findings which contribute to aging of the skin.
Photoaging and infrared radiation. Novel aspects of molecular mechanisms. [2003.09]
Human skin is exposed to infrared (IR) radiation (760 nm-1 mm) from natural and artificial sources. In particular, the use of IR for cosmetic and "wellness" purposes has become increasingly popular and viewed as completely safe.Since this mechanism is a major pathophysiologic factor in UV-induced skin ageing, its activation by IR radiation points to a role of IR in premature skin ageing and indicates the potential need for protection against unwanted IR effects.
Is combined oral and topical therapy better than oral therapy alone in patients with moderate to moderately severe acne vulgaris? A comparison of the efficacy and safety of lymecycline plus adapalene gel 0.1%, versus lymecycline plus gel vehicle [2003.09]
This multicenter, randomized, investigator-blinded study compared the efficacy and tolerability of a combination of lymecycline 300 mg/day orally and adapalene topical gel 0.1% (n = 118) to lymecycline 300 mg/day orally plus vehicle gel (n = 124) in patients with moderate to moderately severe acne vulgaris with both inflammatory and noninflammatory lesions...
Intrinsic skin aging. A critical appraisal of the role of hormones. [2003.09]
Intrinsic skin aging is determined primarily by genetic factors and hormonal status.Since the skin not only fulfils a protective function for the organism but is also an active peripheral endocrine organ, which even releases effective hormones in the circulation, local hormone substitution could become interesting in the future.
Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. [2003.09]
This multicenter, randomized, investigator-blinded study investigated the efficacy and tolerability of adapalene gel 0.1% plus clindamycin phosphate lotion 1%, compared with clindamycin plus vehicle for the treatment of mild to moderate acne vulgaris... Although the worst scores for scaling (P <.05), dryness (P <.01), and stinging/burning (P <.05) were higher in the clindamycin plus adapalene group than in the clindamycin plus vehicle group in patients with moderate or severe irritation; in most cases these symptoms were of mild intensity.
Effect of topical tretinoin, chemical peeling and dermabrasion on p53 expression in facial skin. [2003.09]
The tumour suppressor protein p53 is a
phosphoprotein that is activated by DNA damage. It is involved in the decision whether the cells should stop replication and proceed to repair their DNA, or to die by apoptosis... These changes in the expression of p53 may play a role in mediating the effects of such treatment modalities on the epidermis, as well as prevention of actinic neoplasia by adjusting any disturbance in the proliferation/apoptosis balance observed in photoaged facial skin.
Cumulative irritancy comparison of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents. [2003.09]
This randomized, investigator-blinded study evaluated the level of skin tolerance to adapalene gel 0.1%, tretinoin cream 0.025%, or tretinoin microsphere gel 0.1% when applied in combination with clindamycin phosphate lotion 1%, erythromycin gel 2%, benzoyl peroxide gel 5%, or erythromycin-benzoyl peroxide gel.
Atrophic and a mixed pattern of acne scars improved with a 1320-nm Nd:YAG laser. [2003.09]
CONCLUSION: The 1320-nm Nd:YAG laser is a safe and effective nonablative modality for the improvement of atrophic and a mixed pattern of facial acne scars.
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