Ultraviolet radiation exposure accelerates the accumulation of the aging-dependent T414G mitochondrial DNA mutation in human skin. [2007.08]
The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the aging process... Taken together, these data significantly contribute to our understanding of the DNA damaging effects of UV exposure and how resultant mutations may ultimately contribute towards premature aging.
The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial. [2007.08]
BACKGROUND: No previous study has sought to examine the influence of dietary composition on acne vulgaris. OBJECTIVE: We sought to compare the effect of an experimental low glycemic-load diet with a conventional high glycemic-load diet on clinical and endocrine aspects of acne vulgaris... CONCLUSION: This suggests nutrition-related lifestyle factors play a role in acne pathogenesis. However, these preliminary findings should be confirmed by similar studies.
Long-pulse pulsed dye laser delivered with compression for treatment of facial lentigines. [2007.08]
BACKGROUND AND OBJECTIVE: The 595-nm long-pulsed dye laser (LPDL) has been used for the treatment of vascular lesions, and although it is well absorbed by blood, it is also well absorbed by melanin. To utilize this device for the treatment of facial lentigines, we attached a glass window to the tip of the laser's handpiece, allowing compression of the skin during treatment. This prospective study aims to evaluate the efficacy and complications of using a LPDL delivered with compression for the treatment of facial lentigines in Asian persons... CONCLUSION: LPDL delivered with the compression method is effective in the treatment of facial lentigines in Asian patients, and the side effect profile is minimal. The compression technique allows the traditional "vascular" LPDL to be used for treating a variety of pigmented lesions.
Enhanced efficacy of photodynamic therapy after fractional resurfacing: fractional photodynamic rejuvenation. [2007.08]
BACKGROUND AND OBJECTIVES: Conventional ablative resurfacing is the gold standard for removing signs of cutaneous photodamage. Despite the excellent results one can achieve with this technique, it is accompanied with significant downtime and risks. Fractional resurfacing and photodynamic therapy (PDT) with aminolevulinic acid (ALA) have been used to improve the signs of photodamage with less downtime. However, independently they do not yield results as good as ablative resurfacing. This pilot study will examine the potential for synergistic effects of combining fractional resurfacing and ALA-PDT... CONCLUSION: This pilot study shows a potential for enhanced clinical results when using combined fractional resurfacing and ALA-PDT compared to fractional resurfacing alone.
A randomized, evaluator-blinded comparison of efficacy of hyaluronic acid gel and avian-sourced hylan B plus gel for correction of nasolabial folds. [2007.08]
BACKGROUND: Five hyaluronic acid (HA)-based, biodegradable dermal fillers are approved by the U.S. Food and Drug Administration for the correction of moderate to severe facial wrinkles and folds. Because satisfactory initial correction can be obtained with all these agents, duration of cosmetic correction is an important distinguishing characteristic. OBJECTIVE: The objective was to compare the efficacy and duration of treatment effects of HA gel and hylan B plus gel for the cosmetic correction of nasolabial folds... CONCLUSION: Both HA gel and hylan B plus gel provide dermal augmentation of nasolabial folds. The magnitude and duration of nasolabial fold correction appear to be greater for the HA gel than for the hylan B plus gel.
A novel method to inject hyaluronic acid: the Fern Pattern Technique. [2007.08]
Nonanimal Stabilized Hyaluronic Acid (NASHA) has proven itself as one of the safest, most versatile dermal fillers with a high patient and physician satisfaction.The Fern Pattern Technique also uses less material to provide a correction that is not visible at rest or during dynamic movement for lines that deepen during a smile, as well as the dynamic lower nasolabial fold.
A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. [2007.07.27]
Light-emitting diodes (LEDs) are considered to be effective in skin rejuvenation. We investigated the clinical efficacy of LED phototherapy for skin rejuvenation through the comparison with three different treatment parameters and a control, and also examined the LED-induced histological, ultrastructural, and biochemical changes...
The inhibitory effect of minocycline on hypertrophic scarring. [2007.07]
BACKGROUND: Matrix metalloproteinases are enzymes that serve to degrade the extracellular matrix, giving them a central role in the inflammatory and wound-healing processes; they have been implicated in the pathophysiology of hypertrophic scarring. The purpose of this study was to examine the effect of minocycline, a matrix metalloproteinase inhibitor, on hypertrophic scarring... CONCLUSIONS: Systemically administered minocycline significantly reduces the severity of hypertrophic scarring in a rabbit model. Although not directly examined in this study, matrix metalloproteinase inhibition is hypothesized to be responsible for this effect.
Management of visible granulomas following periorbital injection of poly-L-lactic Acid. [2007.07]
PURPOSE: Injectable poly-L-lactic acid (PLA) is a recently FDA-approved soft-tissue filler. Although approved only for treatment of HIV-associated lipoatrophy, there has been increased interest in its use for cosmetic purposes. Here we describe a case of a granulomatous reaction to injectable PLA in the inferior periorbital region resulting in visible papules and discuss treatment options... CONCLUSIONS: Given the high frequency of subcutaneous nodule formation reported in early trials of injectable PLA, it is important for physicians to be well informed regarding its potential side-effects and how to minimize risk of adverse reactions. Based on our experience, we suggest that surgical excision is an excellent treatment option for persistent papules and nodules that arise after injection of PLA in the periorbital area.
Control of microcomedone formation throughout a maintenance treatment with adapalene gel, 0.1%. [2007.07]
BACKGROUND: Microcomedones representing the clinically non-visible central precursor lesions of acne are induced by sebaceous hyperplasia as well as altered follicular growth and differentiation, and evolve into both comedones and inflammatory lesions. Thus, targeting microcomedone formation is essential in the prevention and therapeutic control of acne. OBJECTIVE: The aim of this study was to assess the capacity of adapalene gel, 0.1%, to control the number of microcomedones after a combination treatment followed by a maintenance treatment... CONCLUSION: The application of adapalene gel, 0.1% monotherapy daily, or alternately every other day, significantly helps to control the microcomedone count during a 12-week maintenance treatment after a previous combination therapy with benzoyl peroxide in patients with mild to moderate acne.
Community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne. [2007.07]
Acne is characterized by different types of lesions at different stages of development... This study investigated the efficacy and safety of combination therapy with clindamycin 1%-BPO 5% topical gel plus tretinoin microsphere (RAM) gel 0.04% or 0.1% or adapalene (AP) gel 0.1% in moderate to severe acne.
Combined infrared light and bipolar radiofrequency for skin tightening in Asians. [2007.07]
BACKGROUND AND OBJECTIVE: As the demand for non-invasive procedures for skin tightening is increasing, combined optical and radiofrequency (RF) devices have recently emerged. The purpose of this study is to evaluate the safety and efficacy of a device that combined broadband infrared (IR) light (700-2000 nm) and bipolar RF (electro-optical synergy [ELOS]) for non-ablative treatment of facial laxity... CONCLUSION: The combination of broadband infrared light and bipolar radiofrequency produces mild improvement of facial laxity in Asians with no serious adverse sequelae. A high patients' satisfaction is achieved. However, further studies are necessary to demonstrate the long-term effects of the procedure and to optimize treatment parameters. (c) 2007 Wiley-Liss, Inc.
ATP-sensitive potassium channel: a novel target for protection against UV-induced human skin cell damage. [2007.07]
Ultraviolet radiation (UV) induces cell damages leading to skin photoaging and skin cancer. ATP-sensitive potassium (K(ATP)) channel openers (KCOs) have been shown to exert significant myocardial preservation and neuroprotection in vitro and in vivo, and yet the potential role of those KCOs in protection against UV-induced skin cell damage is unknown...
A two-stage phase I trial of Evolence30 collagen for soft-tissue contour correction. [2007.07]
BACKGROUND: The ideal dermal filler should be nonpermanent but with a durable effect lasting between 1 and 2 years, which is not the case with the resorbable fillers that are currently available. Evolence30 is a new, porcine-derived collagen gel based on the Glymatrix cross-linking technology, which results in a more natural and longer-lasting collagen product... CONCLUSIONS: Evolence30 is a new, porcine-derived collagen product based on the Glymatrix cross-linking technology that enables a safe and effective correction of the nasolabial folds. This correction lasts significantly longer than that with Zyplast.
A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. [2007.07]
BACKGROUND: Although the pathogenesis of acne is currently unknown, recent epidemiologic studies of non-Westernized populations suggest that dietary factors, including the glycemic load, may be involved. OBJECTIVE: The objective was to determine whether a low-glycemic-load diet improves acne lesion counts in young males... CONCLUSION: The improvement in acne and insulin sensitivity after a low-glycemic-load diet suggests that nutrition-related lifestyle factors may play a role in the pathogenesis of acne. However, further studies are needed to isolate the independent effects of weight loss and dietary intervention and to further elucidate the underlying pathophysiologic mechanisms.
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation. [2007.06.01]
alpha-Lipoic acid (LA) has been intensely investigated as a therapeutic agent for several diseases, including hepatic disorder and diabetic polyneuropathy. However, the effects of LA or its reduced form, dihydrolipoic acid (DHLA), on cancer chemoprevention has never been reported.
Tretinoin gel microspheres 0.04% versus 0.1% in adolescents and adults with mild to moderate acne vulgaris: a 12-week, multicenter, randomized, double-blind, parallel-group, phase IV trial. [2007.06]
BACKGROUND: Topical retinoids are considered first-line therapy in the treatment of acne vulgaris, yet can be associated with cutaneous irritation, including erythema, peeling, dryness, burning, and itching. Tretinoin gel microsphere (TGM) formulations were developed to minimize these effects. A lower-strength TGM formulation may be desirable to further reduce exposure to tretinoin. OBJECTIVE: This study was conducted to assess the efficacy and safety profile of a lower-dose TGM (0.04%) formulation compared with TGM 0.1% for the treatment of mild to moderate acne vulgaris... CONCLUSIONS: Both TGM 0.04% and TGM 0.1% were associated with reductions in lesion counts in these patients with mild to moderate facial acne. Both concentrations were generally well tolerated. The results suggested an early (week 2) incremental benefit for the use of TGM 0.1% in the treatment of inflammatory lesions.
Treatment of facial acne papules and pustules in Korean patients using an intense pulsed light device equipped with a 530- to 750-nm filter. [2007.06]
BACKGROUND: A rising number of laser- or light-based therapies are addressing the need for effective acne treatments with minimal downtime. OBJECTIVE: The purpose of this study is to evaluate an intense pulsed light (IPL) equipped with a 530- to 750-nm filter for inflammatory acne treatment... CONCLUSION: This new wavelength band of IPL system was safe and effective in improving acne red macules, irregular pigmentation, and skin tone but did not affect inflammatory acne lesion counts on the skin of Asian persons.
Tolerability comparison of adapalene gel, 0.3% versus tazarotene cream, 0.05% in subjects with healthy skin. [2007.06]
BACKGROUND: Topical retinoids, including adapalene and tazarotene, are a primary treatment choice for patients with acne. Adapalene is currently marketed in a 0.1% concentration in gel and cream formulation. A new gel containing a higher concentration (0.3%) of adapalene has been developed. In clinical studies, adapalene 0.1% concentration has proven to be better tolerated than other retinoids in skin treatment. However, the tolerability of adapalene gel 0.3% has yet to be compared to other topical retinoids. PURPOSE: The purpose of this study was to compare the local cutaneous tolerability of adapalene gel 0.3% once daily versus tazarotene cream 0.05% once daily... CONCLUSION: Adapalene gel 0.3% is very well-tolerated with good cosmetic acceptability.
The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians. [2007.06]
CONCLUSION: Both the density and energy of the treatment determines the risk of PIH in dark-skinned patients. Density may be of more important but further studies are necessary to determine this. Cooling to prevent bulk tissue heating is also important, especially in small anatomical areas. By using adequate parameters, the risk of PIH in dark-skinned patients can be significantly reduced. (c) 2007 Wiley-Liss, Inc.
The effectiveness and safety of topical PhotoActif phosphatidylcholine-based anti-cellulite gel and LED (red and near-infrared) light on Grade II-III thigh cellulite: a randomized, double-blinded study. [2007.06]
BACKGROUND: Cellulite of the upper lateral and posterior thighs and lower buttocks represents a common, physiological and unwanted condition whose etiologies and effective management are subjects of continued debate. OBJECTIVE: The purpose of this controlled, double-blinded study is to evaluate the efficacy and safety of a novel phosphatidylcholine-based, cosmeceutical anti-cellulite gel combined with a light-emitting diode (LED) array at the wavelengths of red (660 nm) and near-infrared (950 nm), designed to counter the possible mechanisms that purportedly accentuate the presence of thigh cellulite... CONCLUSIONS: The results of this small but well-documented, randomized, double-blinded study affirms that eight of nine thighs with Grade II-III cellulite responded positively to a novel, combined 3-month treatment program of a phosphatidylcholine-based, anti-cellulite gel and LED exposure, as determined by the clinical determinants obtained. Patients experienced minimal and transient side effects. At the month-18 evaluation period (15 months after treatment), five responsive thighs reverted back to their original cellulite grading, indicating a need for maintenance treatment. Future studies are needed to verify these tentative positive observations.
Study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris. [2007.06]
Combination therapy is the standard of care in the management of acne vulgaris... This 12-week study evaluated the safety and efficacy of initial topical benzoyl peroxide 5%/clindamycin 1% gel as monotherapy and in combination with adapalene gel versus adapalene gel monotherapy in the management of acne.
Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy. [2007.06]
CONCLUSION: Analysis of tumor EGFR mutations in patients with NSCLC could be used to identify patients suitable for treatment with gefitinib to obtain optimum response and disease control rates.
In vivo skin antioxidant effect of a new combination based on a specific Vitis vinifera shoot extract and a biotechnological extract. [2007.06]
CONCLUSIONS: Vitis vinifera shoot extract appears to have significantly stronger in vitro antioxidant capacity than vitamin C or vitamin E. In the same vehicle (placebo emulsion), ascorbic acid (0.5%), Sarmentine (1%), and the Sarmentine (1%) plus Ronacare Hydroine (1%) combination had a significant in vivo antioxidant effect versus a nontreated area. The combination Sarmentine (1%) plus Ronacare Hydroine (1%) showed a higher efficacy than Sarmentine alone. The dermatologic evaluation showed that a 4-week twice-daily application of a serum containing the combination improved the main clinical signs of photoaged skin. The addition of the cream with the serum appears to enhance the serum-induced improvement of most of the skin characteristics.
Fractional photothermolysis for the treatment of telangiectatic matting: a case report. [2007.06]
BACKGROUND: Recent reports have demonstrated clinical and histologic evidence of the potential benefit of fractional photothermolysis (1550 nm Fraxel SR laser) for the treatment of dermal vascular lesions. This report evaluated the potential efficacy of fractional photothermolysis for the treatment of matted telangiectasias... CONCLUSION: Fractional photothermolysis is a potentially effective modality for the treatment of matted telangiectasias and warrants further studies. No long-term adverse events were noted and the safety profile appears to be fairly broad.
Effect of laser resurfacing on p53 expression in photoaged facial skin. [2007.06]
BACKGROUND: p53 overexpression has been reported in photoaged skin. Meanwhile, p53 gene mutations have been implicated as an important factor in the pathogenesis of ultraviolet (UV) light-induced skin cancer. OBJECTIVE: The objective was to evaluate the effect of laser resurfacing on the epidermal thickness and expression of p53 in photoaged skin... CONCLUSION: The decrease in epidermal p53 expression after CO(2) and Er:YAG lasers may account for some of the benefits of resurfacing on the epidermis, as well as prevention of actinic neoplasia by adjusting any disturbance in the proliferation/apoptosis balance observed in photoaged facial skin.
Combined effect of anti-inflammatory dose doxycycline (40-mg doxycycline, usp monohydrate controlled-release capsules) and metronidazole topical gel 1% in the treatment of rosacea. [2007.06]
Research into the pathophysiology of rosacea suggests a central role for inflammatory mediators such as nitric oxide (NO), reactive oxygen species (ROS), and matrix metalloproteinases (MMPs). Effective treatments for rosacea, including topical metronidazole and systemic antibiotics, have anti-inflammatory activity, which may be more important than their antimicrobial activity in this setting...
Case reports: clearance of lentigines in Japanese men with the long-pulsed alexandrite laser. [2007.06]
Benign pigmented lesions can be effectively treated with multiple modalities including lasers...
Botulinum neurotoxin type A in facial aesthetics. [2007.06]
Injection of botulinum neurotoxin type A has rapidly become the most common non-surgical cosmetic procedure performed, due to its exceptional safety profile, as well as its ability to rejuvenate and enhance a number of facial areas... It is important for clinicians using these products to understand these differences as they relate to achieving desired outcomes for patients who seek improved facial aesthetics.
Acne and PDT: new techniques with lasers and light sources. [2007.06]
Acne vulgaris is one of the most common dermatologic disorders encountered in everyday practice.More and more clinical trials are showing the effectiveness of 5-aminolevulinic acid and photodynamic therapy in the treatment of moderate to severe inflammatory acne vulgaris.
A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin. [2007.06]
The effects of myristyl nicotinate (MN), a nicotinic acid derivative designed to deliver nicotinic acid to skin without vasodilatation, on subjects with photodamaged skin have been studied...
A pilot study on the use of a plasma skin regeneration device (Portrait PSR3) in full facial rejuvenation procedures. [2007.06]
A new modality, the Portrait plasma skin regeneration (PSR(3)) system, allows precise and rapid treatment of photo-damaged skin, with controlled thermal injury and modification. Radio frequency (RF) energy converts nitrogen gas into plasma within the handpiece.The Rhytec Portrait PSR(3) system provides an attractive alternative to standard lasers that is well tolerated by patients, stimulates collagen remodeling, and provides excellent clinical outcomes.
Effect of Camellia japonica oil on human type I procollagen production and skin barrier function. [2007.05.30]
Type I collagen is the primary component of the skin dermis... Therefore, based on these results, we suggest the possibility that CJ oil may be considered as possible wrinkle-reducing candidates for topical application.
Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosacea. [2007.05]
BACKGROUND: Doxycycline monotherapy at antimicrobial doses has been shown to be effective for the treatment of rosacea. OBJECTIVE: To evaluate the efficacy and safety of once-daily anti-inflammatory dose doxycycline for the treatment of rosacea... CONCLUSION: Once-daily anti-inflammatory dose doxycycline appears to be effective and safe for the treatment of rosacea.
The use of hybrid radiofrequency device for the treatment of rhytides and lax skin. [2007.05]
CONCLUSION: The Accent system is an effective and safe modality for the improvement of age-related rhytides and lax skin.
The face recurve concept: medical and surgical applications. [2007.05]
The application of the Face Recurve theory gives rise to new technical opportunities in the fields of both aesthetic medicine and aesthetic surgery to block the action of the age marker fascicules largely responsible for aging of the paramedian folds.Facial contour is improved, whereas the specific glide is restored between muscles and their underlying fat.
Photodynamic therapy with lasers and intense pulsed light. [2007.05]
For many physicians, photodynamic therapy has become a routine part of using lasers and light sources to improve the outcomes of photorejuvenation therapies. Aminolevulinic acid photodynamic therapy (ALA-PDT) was first used in the treatment of actinic keratoses in the United States... This article reviews the peer-reviewed literature regarding ALA-PDT in photorejuvenation and also summarizes the author's own techniques in using this new and exciting therapeutic method.
Monopolar radiofrequency skin tightening. [2007.05]
The development of nonablative monopolar capacitive radiofrequency technology (ThermaCool System, Thermage, Inc., Hayward, California) has contributed to the noninvasive trend in facial skin rejuvenation. In contrast to traditional ablative resurfacing techniques, the ThermaCool System protects the skin surface from injury while selectively heating the underlying dermis.
Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. [2007.05]
BACKGROUND: Rosacea is an extremely common chronic dermatosis affecting an estimated 14 million Americans. Rosacea is most commonly managed with topical metronidazole, sometimes in combination with oral antibiotics... Maintenance treatment with topical metronidazole decreases relapses and allows for longer intervals between flares.
Improvement of naturally aged skin with vitamin A (retinol). [2007.05]
OBJECTIVE: To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin... CONCLUSIONS: Topical retinol improves fine wrinkles associated with natural aging. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement. With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance.
Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair. [2007.05]
Human skin is constantly exposed to numerous noxious physical, chemical and environmental agents.New mechanistic information strongly supports and explains the chemopreventive activity of GTPs against photocarcinogenesis.
Fractionated photothermolysis: the Fraxel 1550-nm glass fiber laser treatment. [2007.05]
The carbon dioxide laser has been long considered to be the gold standard for cosmetic skin resurfacing. Although Fraxel laser treatment results are in general not as dramatic as with carbon dioxide lasering, they still are remarkable, measurable, and consistent...
Fractional photothermolysis: a novel aesthetic laser surgery modality. [2007.05]
The ubiquity of increased sun exposure, oral contraceptives, and phototoxic drugs has led to an increased prevalence of conditions such as dyschromia, melasma, rhytides, and other signs of photoaging over the past few decades... This review sheds light on the technical aspects, biologic mechanisms, and clinical effects of fractional photothermolysis that help set it apart from previous modes of laser surgery.
Facial anti-wrinkle cream: influence of product presentation on effectiveness: a randomized and controlled study. [2007.05]
BACKGROUND/AIMS: The great interest in eternal youth has developed a large market for skin care products claiming anti-wrinkle effects. A high-priced luxurious anti-wrinkle cream dispensed in its original packaging and in a neutral jar, were compared with the effects from a regular moisturizing face cream in a luxurious jar... CONCLUSIONS: The present study conducted as a formal trial could not verify a claim of anti-wrinkle effect of a known prestigious product. Surprisingly, there was no systematic effect on subjective and objective cosmetic parameters of the luxury packaging, except a better compliance. Product appreciation by consumers may, however, be different in spontaneous use not biased by study conditions.
Evaluation of efficacy and safety of rucinol serum in patients with melasma: a randomized controlled trial. [2007.05]
BACKGROUND: Melasma is a hyperpigmentation disorder predominantly affecting sun-exposed areas in women, which is often refractory to treatment. Most commercially available treatments incorporate inhibitors of tyrosinase, a key enzyme in melanin production within the melanocyte. In general, however, the efficacy of these therapies is somewhat limited. Recent studies have identified other enzymes that play an important role in melanogenesis, including tyrosinase-related protein-1 (TRP-1), which catalyses the oxidation of the melanogenetic intermediate 5,6-dihydroxyindole-2-carbolylic acid. Rucinol (4-n-butylresorcinol) has been shown to inhibit the activity of both tyrosinase and TRP-1. OBJECTIVES: To assess the efficacy of rucinol serum 0.3% vs. the corresponding vehicle as a treatment for melasma. Secondary objectives were to evaluate local and general tolerability and to assess the skin acceptability of rucinol serum in the target population... CONCLUSIONS: Rucinol serum was shown to have significant efficacy compared with vehicle alone in improving melasma after 3 months of treatment, according to clinical and objective assessments of skin colour.
Effects of polyphenols on skin damage due to ultraviolet A rays: an experimental study on rats. [2007.05]
CONCLUSION: These results show a protective effect of EGCG when applied topically before UVA exposure. No benefit was detected when EGCG was applied after UV exposure.
Bipolar radiofrequency for facial rejuvenation. [2007.05]
Combined approaches using light and radiofrequency represent an innovative approach to whole body rejuvenation.In addition, by using lower levels of light energy, darker skin phenotypes can be treated with a lower risk for pigment dyschromia and scarring.
Azelaic acid (15% gel) in the treatment of acne rosacea. [2007.05]
In December of 2002, the FDA approved azelaic acid 15% gel for the topical treatment of inflammatory papules and pustules of mild to moderate rosacea. Azelaic acid is a saturated dicarboxylic acid, which is naturally occurring and has been used in the treatment of rosacea, acne, and melasma.
A randomized, evaluator-blinded, two-center study of the safety and effect of volume on the diffusion and efficacy of botulinum toxin type A in the treatment of lateral orbital rhytides. [2007.05]
CONCLUSIONS: This is a small study and it may be that dilution does affect BTX result. We were, however, unable to detect any difference in this study, which suggests that the degree of dilution, at least within a fivefold margin, has only a small effect on the results of BTX injection in the lateral orbital area.
A randomized trial to determine the influence of laser therapy, monopolar radiofrequency treatment, and intense pulsed light therapy administered immediately after hyaluronic acid gel implantation. [2007.05]
BACKGROUND: Hyaluronic acid-based dermal fillers, such as hyaluronic acid gel (Restylane, Q-Medical AB, Uppsala, Sweden), are widely used for tissue augmentation of the nasolabial folds. Additional dermatologic treatments using infrared light, radiofrequency (RF), and intense pulsed light (IPL) are also important tools for facial rejuvenation. This study was designed to evaluate whether these therapies could be safely administered immediately after hyaluronic acid gel treatment without compromising the effect of the dermal filler. OBJECTIVE: The objective of this study was to confirm or refute any possible subtractive effects of augmentation of the nasolabial folds when followed by 1,320-nm Nd:YAG laser, 1,450-nm diode laser, monopolar RF, and/or IPL treatments... CONCLUSIONS: Based on this small pilot study, laser, RF, and IPL treatments can safely be administered immediately after hyaluronic acid gel implantation without reduction in overall clinical effect.
Treatment of pigmented lesions of neurofibromatosis 1 with intense pulsed-radio frequency in combination with topical application of vitamin D3 ointment. [2007.04]
Cafe-au-lait spots and pigmented freckling are found in most of patients with neurofibromatosis 1 (NF1)... Although further studies with large groups of patients should be performed for a better conclusion, it could improve quality of life with NF1 patients who are concerned with serious cosmetic and social problems.
Stability of vitamins C and E in topical microemulsions for combined antioxidant therapy. [2007.04]
An interesting strategy for protecting skin from excessive exposure to free radicals is to support the skin endogenous antioxidant system. As the balance between different skin antioxidants is very important, a combined therapy using at least two antioxidants is desirable... It is likely that the changes in internal organization of ME resulting from the addition of thickener, confirmed by thermal analysis and changes in solubility of oxygen in the outer phase, were the most important factors that influenced the stability of vitamins in thickened systems.
Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians. [2007.04]
BACKGROUND AND OBJECTIVE: Fractional resurfacing is a new concept of cutaneous remodeling whereby laser-induced zones of microthermal injury are surrounded by normal untreated tissue. The aim of this study is to compare the efficacy and complications of Fraxel laser treatment when using different fluences and density settings... CONCLUSION: Increased density was more likely to produce swelling, redness, and hyperpigmentation when compared to increased energy. Patient satisfaction is significantly higher when their skin is treated with high fluences, but not when patients' skin is treated with high densities. (c) 2007 Wiley-Liss, Inc.
Pimecrolimus cream 1% for papulopustular rosacea: a randomized vehicle-controlled double-blind trial. [2007.04]
BACKGROUND: Rosacea remains difficult to treat, despite many therapeutic options. OBJECTIVES: To investigate the effect of pimecrolimus cream 1% (Elidel; Novartis Pharma, Nuremberg, Germany) in the treatment of papulopustular rosacea... CONCLUSIONS: Treatment of rosacea for 4-8 weeks with the topical calcineurin inhibitor pimecrolimus cream 1% was not more efficacious than treatment with the vehicle cream.
Objective evaluation of the effect of intense pulsed light on rosacea and solar lentigines by spectrophotometric analysis of skin color. [2007.04]
BACKGROUND: To date, intense pulsed light (IPL) has been applied to various skin diseases, but there have been few objective evaluations of its efficacy. OBJECTIVE: The aim of this study was to perform objective evaluations of the effect of the IPL system on rosacea and solar lentigines... CONCLUSION: As demonstrated by spectrophotometric analysis of skin color, IPL at the wavelength of 550 to 670 nm is effective for rosacea and solar lentigines, particularly most useful for erythematotelangiectatic rosacea.
Nonsurgical tightening of skin laxity: a new radiofrequency approach. [2007.04]
BACKGROUND: Improvement in skin laxity can be difficult to achieve without invasive surgical procedures.There were no significant complications and the majority of patients were satisfied with the procedure and able to return to their daily routine after leaving the office, thereby substantiating the popularity of noninvasive rejuvenating procedures.
A pilot study on the effect of epinephrine on botulinum toxin treatment for periorbital rhytides. [2007.04]
BACKGROUND: Relaxation of hyperactive facial muscles by injection of botulinum toxin type A (BOTOX, Allergan Inc., Irvine, CA) represents the most common cosmetic procedure performed in the United States. OBJECTIVE: The objective of this split-face randomized double-blind study was to determine the effect of epinephrine (EPI) on the efficacy of BOTOX treatment of muscle hyperactivity in the upper face... CONCLUSION: To our knowledge, we are the first to test under randomized double-blind conditions the effect of EPI on efficacy of BOTOX. Our data suggest that addition of EPI may accelerate the rate of onset as well as the short-term efficacy of BOTOX for treatment of periorbital rhytides.
Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. [2007.03]
BACKGROUND: A new aqueous gel formulation of dapsone has been developed that allows clinically-effective doses of dapsone to be administered topically with minimal systemic absorption. OBJECTIVES: The goal of these studies was to evaluate the efficacy and safety of dapsone gel, 5% in the treatment of acne... CONCLUSIONS: Dapsone gel, 5% appears to be an effective, safe, and well-tolerated treatment for acne vulgaris, with a rapid onset of action.
Treatment of wrinkles and elastosis using vacuum-assisted bipolar radiofrequency heating of the dermis. [2007.03]
BACKGROUND: Reduction of wrinkles is increasingly becoming one of the most sought after aesthetic procedures. A variety of treatment modalities are available for this application, including radiofrequency energy in various modes of action. OBJECTIVE: The goal of the reported study was to evaluate the safety and efficacy of a new device, which implements an innovative combination of bipolar radiofrequency and vacuum... CONCLUSIONS: Our results demonstrate the safety and efficacy associated with use of this radiofrequency and vacuum device, employing Functional Aspiration Controlled Electrothermal Stimulation (FACES) technology, for reduction of facial wrinkles and elastosis.
Treatment of skin laxity of the lower face and neck in older individuals with a broad-spectrum infrared light device. [2007.03]
BACKGROUND: Non-ablative approaches with infrared and radiofrequency energy sources have been shown to reduce skin laxity, but studies have focused on individuals with early-stage, mild-to-moderate degenerative dermal changes. OBJECTIVE: The purpose of this prospective study was to evaluate the safety and efficacy of an infrared light device for the treatment of skin laxity in patients with soft tissue ptosis of the lower face and neck characteristic of the sixth decade of life and beyond... CONCLUSION: Infrared light source-induced skin tightening may be induced even in older individuals.
The use of fractional laser photothermolysis for the treatment of atrophic scars. [2007.03]
BACKGROUND: Patients with atrophic scars commonly seek treatment for their removal but are often concerned about the prolonged recovery, short-lived results, and/or ineffectiveness of available therapies. A novel treatment using a 1,550-nm erbium-doped fiber laser to induce fractional photothermolysis of treated skin has been used to resurface photodamaged skin but has not been studied previously in patients with atrophic scars to determine its effectiveness for this condition. PURPOSE: To determine the effectiveness and safety of 1,550-nm erbium-doped fiber laser treatment on atrophic scars... CONCLUSIONS: Atrophic scars can be effectively and safely reduced with 1,550-nm erbium-doped fiber laser treatment.
The effect of azithromycin on reactive oxygen species in rosacea. [2007.03]
BACKGROUND: Recent evidence suggests that inflammation in rosacea is associated with generation of reactive oxygen species (ROS) that are released by inflammatory cells. The efficacy of current therapeutic agents for rosacea such as tetracyclines and metronidazole has also been attributed to their antioxidant properties. Recently, a macrolide antibiotic, azithromycin, has been found to be an effective alternative in the treatment of rosacea. AIM: We planned a study to evaluate the antioxidant effects of azithromycin on ROS in rosacea. We compared basal ROS concentrations measured in the facial skin of patients with rosacea with the post-treatment levels and with those of healthy controls... CONCLUSION: Rosacea patients have higher ROS levels than healthy controls. The results of our study support the antioxidant properties of azithromycin in rosacea.
The "golden thread lift": radiologic findings. [2007.03]
A 48-year-old patient reported pain in her face and neck.Skull radiographs showed complete fragmentation of all the implants into small pieces, and a total loss of their vector orientation.
Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. [2007.03]
BACKGROUND: Acne is a multifactorial disorder in which the sebum plays an important pathogenetic role. PURPOSE OF THE STUDY: To evaluate the sebostatic effect of three anti-acneic ingredients (azelaic acid, adapalene and benzoyl peroxide) conveyed in cream and to determine whether there is a correlation with the therapeutic results... CONCLUSION: The three topical drugs bring about good therapeutic results with scarce side-effects that do not, however, seem to be correlated with the sebostatic activity.
Fraxel skin resurfacing. [2007.03]
Fractional photothermolysis is a new skin resurfacing laser technology for treating wrinkles, melanocytic pigmentation, scars, and photodamaged skin. Treatment with the Fraxel laser (Reliant Technologies, Inc.) creates microzones of injury in the skin that are surrounded by normal intervening skin that rapidly heals the injured tissue...
Fractional resurfacing for the treatment of hypopigmented scars: a pilot study. [2007.03]
BACKGROUND: Treatments for hypopigmented scars have shown limited efficacy and variable safety profiles. OBJECTIVE This study evaluated the safety and efficacy of fractional resurfacing (1,550-nm Fraxel SR laser, Reliant Technologies, Mountain View, CA) for the treatment of hypopigmented scars on the face in seven patients... CONCLUSION: Fractional resurfacing is a potentially effective modality for the treatment of hypopigmented scarring on the face. No adverse effects were observed.
Formulation, characterization, and efficacy of an adenosine-containing dissolvable film for a localized anti-wrinkle effect. [2007.03]
A water-dissolvable film was developed to topically deliver adenosine for a localized anti-wrinkle effect. The polymers used to produce the film were cellulose derivatives... These results demonstrate that water-dissolvable films may be used as novel, preservative-free, cosmetic delivery systems.
Evaluation of the multiple pass, low fluence algorithm for radiofrequency tightening of the lower face. [2007.03]
BACKGROUND AND OBJECTIVE: Non-ablative monopolar radiofrequency technology delivers heat to the deep dermis and subdermal layers of the skin to improve facial laxity. The purpose of this study is to evaluate the multiple pass, low fluence treatment algorithm for lower face laxity... CONCLUSION: The low-fluence, multiple pass technique is an effective algorithm for radiofrequency skin tightening. (c) 2007 Wiley-Liss, Inc
Elderly skin and its rejuvenation: products and procedures for the aging skin. [2007.03]
In the last few decades, there has been a substantial increase in the population of people over 60 years of age... The use of makeup and the adverse reactions to cosmetics will also be mentioned.
Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris. [2007.03]
BACKGROUND: Twenty percent azelaic acid gel is recommended as a topical treatment for acne due to its favorable profile. AIM: Our objective in this study was to evaluate the efficacy of 20% azelaic acid gel in the treatment of mild to moderate acne vulgaris... CONCLUSION: Azelaic acid gel can be used as an effective treatment in mild to moderate acne vulgaris.
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