[Evaluation of a compound with dan-shen root and azone for scar treatment]

Author: Chen J, Han CM, Dong HL, Qi FZ, Chen GS

Author affiliation: Burns Department Zhejiang Province Ruian People Hospital, Ruian 325200, China.

Publication date & source: 2004.05, Zhonghua Zheng Xing Wai Ke Za Zhi., 20(3):219-21.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: To evaluate the effect of the compound of Dan-shen root and azone for scar treatment. METHODS: The rat skin in vitro and the human skin in vitro and vivo were separately examined their permeability of the mixture of the Dan-shen root and azone. The 301 patients with hypertrophic scar were randomly divided into two groups: one treated with elastic cloth paste (including silicone) contained in Dan-shen root with azone, and the another treated with only elastic cloth paste (including silicone). RESULTS: The permeability of Dan-shen root with azone, passing through the rat skin in vitro and the human skin in vitro and vivo was significantly higher than both the distilled water and the normal saline (P < 0.05). In the clinical study for treatment of the hypertrophic scars, the efficient rate of the group with the Dan-shen root with azone was significantly higher than the control (91.4% vs. 71.3%) (P < 0.01). CONCLUSION: The Dan-shen root with azone could be easier to permeate the skin and more effective to treat the hypertrophic scar.

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