A prospective split-face double-blind randomized placebo-controlled trial to assess the efficacy of methyl aminolevulinate + red-light in patients with facial photodamage. [2011.01]
To date, there is no gold standard therapy for skin photoageing. In the last decade, laser technologies have offered great promise among skin-rejuvenation therapies; however, both non-ablative and ablative fractional resurfacing modalities have their own benefits and drawbacks.More recently, open-label studies and few controlled trials have suggested that photodynamic therapy may have therapeutic potential in photodamage.
Factors Associated with Premature Skin Aging (Photoaging) before the Age of 55: A Population-Based Study. [2010.12.29]
Background: Precise factors associated with premature skin aging, or photoaging, in the general population are unknown...
Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications. [2010.11]
This paper continues our review of scientifically evaluated plant extracts in dermatology. After plants effective against dermatophytes, botanicals with anti-edema effects in chronic venous insufficiency are discussed... (c) The Authors * Journal compilation (c) Blackwell Verlag GmbH, Berlin.
Inhibitory effect of encapsulated curcumin on ultraviolet-induced photoaging in mice. [2010.08]
Photoaging is the superposition of photodamage (ultraviolet [UV] radiation-induced) on the aging process...
Protecting skin photoaging by NF-kappaB inhibitor. [2010.06.01]
The skin photoaging is an inevitable process that occurs in daily life. It ischaracterized by acceralated keratinocyte proliferation and degradation of collagen fibers, causing skin wrinkling and laxity, and melanocyte proliferation that leads to pigmentation...
Estrogen receptor beta is a novel therapeutic target for photoaging. [2010.05]
One of the many harmful factors faced by the skin is solar UV radiation, which damages skin by inducing chronic low-grade inflammation through increased expression of proinflammatory cytokines, metalloproteinases (MMPs) and cyclooxygenase-2 (COX-2). Estrogen receptors (ERs) alpha and beta are ligand-dependent transcription factors that are expressed in skin, and an ERbeta agonist has previously shown efficacy in vivo in models of pain and inflammation...
Anti-photoaging and photoprotective compounds derived from marine organisms. [2010.04.08]
Marine organisms form a prominent component of the oceanic population, which significantly contribute in the production of cosmeceutical and pharmaceutical molecules with biologically efficient moieties. In addition to the molecules of various biological activities like anti-bacterial, anti-cancerous, anti-inflammatory and anti-oxidative etc., these organisms also produce potential photoprotective or anti-photoaging agents, which are attracting present day researchers...
Mechanistic insights in the use of a Polypodium leucotomos extract as an oral and topical photoprotective agent. [2010.04]
Photoprotection is essential to prevent the deleterious effects of ultraviolet (UV) light, including skin cancer, photoaging and immunosuppression...
Effects of topical boswellic acid on photo and age-damaged skin: clinical, biophysical, and echographic evaluations in a double-blind, randomized, split-face study. [2010.04]
Boswellic acids (BAs) are pentacyclic triterpenes with strong anti-inflammatory activity; their most important source is the extract of the gum resin of Boswellia serrata, a tropical tree that grows in India and Africa. In the present randomized, double-blind, split-face, comparative study we have assessed efficacy, tolerability, and safety of a base cream containing 0.5 % BAs as compared to the same cream without these active ingredients in the treatment of clinical manifestations of photoaging of facial skin...
Labisia pumila extract protects skin cells from photoaging caused by UVB irradiation. [2010.03]
Labisia pumila (Myrsinaceae), known as "Kacip Fatimah," has been used by many generations of Malay women to induce and facilitate child birth as well as a post partum medicine. However, its topical application on skin has not been reported yet.
Topical Boswellic acids for treatment of photoaged skin. [2010.01]
Boswellic acids (BAs) are pentacyclic triterpenes extracted from the gum resins of the tropical tree Boswellia serrata. They are orally administered in traditional Indian medicine for the treatment of several inflammatory disease and cancer because of their anti-inflammatory and immunomodulatory activities as well as stimulatory effects on fibroblasts...
Photoprotection: a review of the current and future technologies. [2010.01]
Exposure to ultraviolet (UV) radiation is associated with a variety of harmful effects ranging from photoaging to skin cancer... Lastly, we reviewed alternative agents, such as antioxidants, that can be used to supplement and augment photoprotection provided by sunscreens.
Photoprotection beyond ultraviolet radiation--effective sun protection has to include protection against infrared A radiation-induced skin damage. [2010]
Solar radiation is well known to damage human skin, for example by causing premature skin ageing (i.e.
DNA damage responses in skin biology--implications in tumor prevention and aging acceleration. [2009.11]
UV irradiation is the main etiological cause of most types of skin cancers and can accelerate skin photoaging.In this review, changes in chromatin modification in response to UV and the molecular mechanisms accelerating aging phenotypes are discussed.
Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compounds. [2009.09]
BACKGROUND: Sunscreens have long been used to protect against the acute effects of UV radiation. They can also have protective effects on chronic UV-induced changes, such as photoaging and skin cancer. Recent studies have focused on marine organisms as a source of natural bioactive molecules and some UV-absorbing algal compounds are under investigation as candidates for new natural sunscreens. OBJECTIVE: The cutaneous photoprotective ability of the mycosporine-like aminoacids (MAAs) Porphyra-334 and shinorine (P-334+SH), high UV-absorbing compounds isolated from the red alga Porphyra rosengurttii, was evaluated by in vivo procedures in mouse skin. The expression of the heat shock protein HSP70 as a potential biomarker for acute UV damage was also investigated... CONCLUSION: The topical application of P-334+SH protected against UV-induced skin damage in mice and contributed to maintaining the antioxidant defence system of the skin as well as Hsp70 expression.
The pathogenesis of photoaging: the role of neutrophils and neutrophil-derived enzymes. [2009.08]
The hallmark of photoaged skin is solar elastosis, which is probably an end product of elastic fiber degradation.Although several groups have shown that MMPs are also induced in skin exposed to relatively low doses of UV, IR, and heat, clinical data indicate that high(er) doses of UV, IR, and heat are necessary to induce photoaging or photoaging-like pathology in the skin.
Telomere-mediated effects on melanogenesis and skin aging. [2009.08]
UV-induced melanogenesis (tanning) and "premature aging" or photoaging result in large part from DNA damage.
Role of mitochondria in photoaging of human skin: the defective powerhouse model. [2009.08]
The exact pathogenesis of photoaging of the skin is not yet known. Earlier, a number of molecular pathways explaining one or more characteristics of photoaged skin have been described, but a unifying mechanistic concept is still missing... As a consequence of this defective powerhouse, retrograde mitochondrial signaling pathways are triggered that then they transduce functional and structural alterations in the skin.
Non-sunscreen photoprotection: antioxidants add value to a sunscreen. [2009.08]
The association between ultraviolet radiation (UVR) exposure and both skin cancer and photo-aging is well documented.These agents have been shown to enhance protection against UV-induced epidermal thickening, overexpression of MMP-1and MMP-9, and depletion of CD1a(+) Langerhans cells.
Effects of infrared radiation and heat on human skin aging in vivo. [2009.08]
Sunlight damages human skin, resulting in a wrinkled appearance. Since natural sunlight is polychromatic, its ultimate effects on the human skin are the result of not only the action of each wavelength separately, but also interactions among the many wavelengths, including UV, visible light, and infrared (IR)...
Genomic-driven insights into changes in aging skin. [2009.07]
Like all tissues, the skin ages due to the passage of time (chronologic aging). However, skin is also exposed to external insults, such as sunlight.Bioinformatics tools also enable an integrated analysis of gene expression themes and pathways, which may provide new insights into the mechanisms of skin aging and possible interventions.
Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis. [2009.06]
OBJECTIVE: To examine clinical and molecular changes after topical fluorouracil treatment of photodamaged human facial skin for actinic keratoses... CONCLUSIONS: Topical fluorouracil causes epidermal injury, which stimulates wound healing and dermal remodeling resulting in improved appearance. The mechanism of topical fluorouracil in photoaged skin follows a predictable wound healing pattern of events reminiscent of that seen with laser treatment of photoaging.
Protective role of adipose-derived stem cells and their soluble factors in photoaging. [2009.06]
As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning and loss of elasticity, that are due to both genetic and environmental factors. These changes may worsen, progressing to precancerous and cancerous diseases... Therefore, ADSCs and soluble factors show promise for the treatment of photoaging, and this review introduces recent research developments of the ADSCs and ADSC-derived secretory factors regarding this issue.
Prevention of infrared-A radiation mediated detrimental effects in human skin. [2009.06]
Photoaging and skin damage that is caused by solar radiation is well known. We have recently learned that within the solar spectrum this damage not only results from ultraviolet (UV) radiation, but also from longer wavelengths, in particular near infrared radiation.
Effect of untreated and photobleached bovine RPE melanosomes on the photoinduced peroxidation of lipids. [2009.06]
Melanin is usually considered a photoprotective pigment and antioxidant agent, but it is unclear how melanosomes protect pigmented cells against oxidative stress induced by light and whether aging modulates its photoprotective function, particularly in long-lived post-mitotic cells such as the retinal pigment epithelium (RPE)...
Synergistic damage by UVA radiation and pollutants. [2009.05]
Not only is skin cancer by far the most common human cancer but also the incidence of skin cancer has been increasing at an alarming rate in recent decades. Fortunately, most people now realize that sun exposure causes unattractive photoaging and skin cancer, so they do apply sunscreens conscientiously.
Photoprotective effect of red ginseng against ultraviolet radiation-induced chronic skin damage in the hairless mouse. [2009.03]
To evaluate the ability of red ginseng (RG) to protect the skin from photodamage, the gross and microscopic changes in the skin of hairless mice and RG-treated mice exposed chronically to UV were examined. The skin of the UV-irradiated mice showed characteristic signs of photoaging, such as deep wrinkles across the back, increased epidermal thickness, numerous cell infiltration, and many enlarged keratinizing cysts...
Cosmeceuticals: focus on topical retinoids in photoaging. [2008.11]
Evidence from a randomized clinical trial showed that, in spite of the many surgical procedures effective in ameliorating the clinical appearance of photoaged skin, the only medical therapy with proven benefits in photoaged skin are topical retinoids, in particular tretinoin, isotretinoin, and tazarotene.
Molecular effects of photodynamic therapy for photoaging. [2008.10]
OBJECTIVE: To quantitatively examine the epidermal and dermal cellular and molecular changes that occur after photodynamic therapy of photodamaged human skin... CONCLUSIONS: Photodynamic therapy with the specific treatment regimen employed produces statistically significant quantitative cutaneous molecular changes (eg, production of types I and III collagen) that are associated with improved appearance of the skin. Baseline epidermal p53 immunostaining levels may be predictive of dermal responses to this therapy. Comparison with historical data using pulsed-dye laser therapy alone suggests that use of the photosensitizer may enhance dermal remodeling. The quantitative in vivo molecular data presented herein are in keeping with an evolving model to potentially predict the efficacy of new techniques for the treatment of photoaging.
Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. [2008.08]
BACKGROUND: UVA exposure of human skin mainly produces reactive oxygen species (ROS) leading to DNA, cell and tissue damage. It alters immune function, pigmentation and it is certainly responsible for a large part of photoaging changes. Moreover UVA is implicated in the etiology of several photodermatoses. As a consequence, to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones. AIM: To assess the efficacy of sunscreens containing a broad-spectrum UVA absorber the Mexoryls SX or ecamsule and to compare formulations with and without it through a large number of clinical studies in human volunteers and patients... CONCLUSION: Mexoryls SX formulated in sunscreens or daily use products have been shown to be an effective UV absorber, leading to an increased efficacy of these products against a large number of biological damage induced by UVA, SSR or sun exposure.
Skin nonpenetrating sunscreens for cosmetic and pharmaceutical formulations. [2008.07]
Ultraviolet (UV) solar radiation produces harmful effects on the skin including sunburn, local immunosuppression, skin photoaging, and cutaneous malignancies. Although application of sunscreens is the "gold standard" for protecting the skin from UV radiation, studies have shown that currently used sunscreens can cause adverse skin and systemic reactions, owing to their penetration into the viable cutaneous strata and to transdermal absorption...
In vivo three-dimensional birefringence analysis shows collagen differences between young and old photo-aged human skin. [2008.07]
Polarization-sensitive optical coherence tomography (PS-OCT) permits non-invasive visualization of dermal birefringence, mainly due to collagenous structures...
The benefit of daily photoprotection. [2008.05]
CONCLUSION: Our in vivo results demonstrate the benefits of daily photoprotection using a day cream containing appropriate broad-spectrum sunscreens, which prevent solar UV-induced skin damages.
Loss of elastic fibers causes skin wrinkles in sun-damaged human skin. [2008.05]
BACKGROUND: Although wrinkling is the most obvious sign of aged skin, the detailed pathomechanism of wrinkle development has not been elucidated. OBJECTIVES: In this study, we investigated the role of elastic fibers in the formation of skin wrinkles... CONCLUSIONS: Our results provide an objective insight into the role of elastic fibers in skin wrinkle formation by providing a quantitative correlation between changes in oxytalan fibers and the severity of skin wrinkling.
The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure. [2008.02]
Cutaneous aging occurs through 2 biologically distinct processes: intrinsic and extrinsic aging. The first is a naturally occurring process that results from slow tissue degeneration.This provides a mechanism for enhanced elastin biosynthesis, which contributes to the clinical and morphologic changes observed in photoaged skin.
Intense pulsed light versus advanced fluorescent technology pulsed light for photodamaged skin: a split-face pilot comparison. [2007.10]
Intense pulsed light (IPL) has been a popular nonablative treatment of photodamage. A prospective, randomized, controlled, single-blinded, split-face pilot study compared the efficacy and safety of 2 multitechnology broadband pulsed light platform devices: an IPL device (Lumenis One, Lumenis Corporation, Santa Clara, CA) and a fluorescent pulsed light with advanced fluorescent technology (AFT, Harmony System, Alma Lasers, Buffalo Grove, IL) device...
Mexoryl: a review of an ultraviolet a filter. [2007.09.15]
It is widely known that ultraviolet light causes skin damage and melanoma. Different wavelengths of ultraviolet light penetrate the skin at different depths, causing varying levels of damage.
Angiogenesis in skin aging and photoaging. [2007.09]
Angiogenesis, the process of generating new blood vessels, is affected by various physiological and pathological conditions of skin.An understanding of the molecular mechanisms of aging- and photoaging-dependent changes of skin angiogenesis may provide us with new insights to prevent and treat the skin aging process.
Ultraviolet radiation exposure accelerates the accumulation of the aging-dependent T414G mitochondrial DNA mutation in human skin. [2007.08]
The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the aging process... Taken together, these data significantly contribute to our understanding of the DNA damaging effects of UV exposure and how resultant mutations may ultimately contribute towards premature aging.
ATP-sensitive potassium channel: a novel target for protection against UV-induced human skin cell damage. [2007.07]
Ultraviolet radiation (UV) induces cell damages leading to skin photoaging and skin cancer. ATP-sensitive potassium (K(ATP)) channel openers (KCOs) have been shown to exert significant myocardial preservation and neuroprotection in vitro and in vivo, and yet the potential role of those KCOs in protection against UV-induced skin cell damage is unknown...
Effect of pre-treatment of almond oil on ultraviolet B-induced cutaneous photoaging in mice. [2007.03]
BACKGROUND: Ultraviolet (UV) radiation has been implicated in photoaging and various types of skin carcinomas. Although the human skin has evolved several defense mechanisms to survive the insults of actinic damage like keratinization, melanin pigmentation, etc., it is still subjected to the harmful effects of sunlight. AIMS: In this study, the role of almond oil in reducing the degradative changes induced in skin upon exposure to UV radiation was investigated... CONCLUSIONS: It was concluded that topical almond oil is capable of preventing the structural damage caused by UV irradiation and it was also found useful in decelerating the photoaging process.
Clinical and echographic analysis of photodynamic therapy using methylaminolevulinate as sensitizer in the treatment of photodamaged facial skin. [2007.03]
BACKGROUND AND OBJECTIVE: Photodynamic therapy (PDT) using aminolevulinic acid (ALA) has been previously investigated in the treatment of photodamaged skin. The aim was to assess efficacy and tolerability of methylaminolevulinate (MAL) as a substitute for ALA in PDT treatment of actinic keratosis (AK) and photoaging... CONCLUSION: MAL-PDT is an effective treatment for multiple AKs. In addition, it improves clinical signs of photodamage of the surrounding skin. (c) 2007 Wiley-Liss, Inc
UV radiation: what we know and do we protect ourselves adequately? [2007.01]
Chronic sun exposure causes degenerative changes in the skin that are recognized as photoaging, immunosuppression and photocarcinogenesis... Encouraging photoprotection and improving the awareness of the general public about the harmful effects of too much sun exposure must be the leading preventative health strategy.
Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. [2006.09]
Exposure of the skin to ultraviolet (UV) radiation, particularly its UV-B component (280-320 nm), from the sun results in erythema, edema, hyperplasia, hyperpigmentation, sunburn cells, immunosuppression, photoaging, and skin cancer.This review will focus on the effects of selected botanical antioxidants in the prevention of photocarcinogenesis and photoaging.
Photoaging: mechanisms and repair. [2006.07]
Aging is a complex, multifactorial process resulting in several functional and esthetic changes in the skin. These changes result from intrinsic as well as extrinsic processes, such as ultraviolet radiation.LEARNING OBJECTIVES: At the conclusion of this learning activity, participants should be familiar with the mechanism of photoaging, the treatments for photoaging, and the data that supports the use of these treatments.
Non-surgical treatment modalities of facial photodamage: practical knowledge for the oral and maxillofacial professional. [2006.05]
With the increasing interest in cosmetic procedures, oral and maxillofacial surgeons are being asked not only to improve oral health and aesthetics but to extend their expertise to provide advice on improving the overall appearance of the face...
Sunscreens with an absorption maximum of > or =360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts. [2006.03]
UVA1-induced expression of matrix metalloproteinase-1 (MMP-1) is mediated by an autocrine mechanism involving the cytokines interleukin-1 and -6 (IL-1 and IL-6). The subsequent degradation of collagen fibers is thought to be the main cause of skin wrinkling... These studies indicate that UVA1 filters with a maximum absorption at > or =360 nm are most effective in preventing UVA1 radiation-induced MMP-1, IL-1alpha, and IL-6 expression pointing towards a critical role for effective filtering beyond > or =360 nm for protection against UVA1-induced photoaging.
Pathophysiology of photoaging of human skin: focus on neutrophils. [2006.02]
UV-induced skin damage is the result of a complex cascade of events.Statement: Although most of the data, referred to, have been published, the current perspective in which they are put together is completely novel and has not been published elsewhere.
Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection. [2006.02]
Endogenous chromophores in human skin serve as photosensitizers involved in skin photocarcinogenesis and photoaging. Absorption of solar photons, particularly in the UVA region, induces the formation of photoexcited states of skin photosensitizers with subsequent generation of reactive oxygen species (ROS), organic free radicals and other toxic photoproducts that mediate skin photooxidative stress.
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