A comparative evaluation of tretinoin gel microsphere, 0.1%, versus tretinoin cream, 0.025%, in reducing facial shine. [2000.08]
Tretinoin gel microsphere, 0.1%, is a highly effective anti-acne medication formulated with sponge-like microspheres encapsulating the active ingredient, tretinoin... Tretinoin gel microsphere, 0.1%, has the added benefit of reducing the appearance of facial shine, which is a frequent concern in acne patients.
Recent developments in receptor-selective retinoids. [2000.06]
Natural (all trans-retinoic acid, RA) and synthetic retinoids exhibit potent anti-proliferative, normalization of differentiation and anti-inflammatory activities which appear to account for their therapeutic effects in acne, psoriasis, photoaging, precancerous lesions and established cancers.The discovery of novel retinoids along with an increased understanding of the biological functions and mechanisms of action of retinoid receptors are likely to result in improved treatments for existing responsive indications and identification of new retinoid therapeutic targets.
Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial. [2000.01]
Photodamaged skin occurs as a result of long-term exposure to ultraviolet radiation. The incidence of photodamage in European and North American populations with Fitzpatrick skin types I, II, and III is estimated at 80% to 90%... Topical application of 0.1% isotretinoin is an effective and well-tolerated treatment leading to clinically apparent improvement in the appearance of photodamaged skin of the face, forearms, and hands.
Interactions between tazarotene and ultraviolet light. [1999.12]
Tazarotene in combination with phototherapy is being used clinically for the treatment of plaque psoriasis. This study investigates the dose of UVB light required to induce minimal erythema and the dose of UVA light required to induce immediate pigment darkening, with and without pretreatment with tazarotene 0.1% gel...
Comparative irritancy study among retinoid creams and gels. [1999.10]
BACKGROUND: Topical retinoids, although very useful in dermatology, may be irritating to some patients. OBJECTIVE: There are a number of topical retinoids available in Canada, and the objective of the present study was to evaluate the irritancy potential in humans of retinoid gels and creams presently available in Canada... CONCLUSION: By several measures, adapalene cream and gel were less irritating upon multiple dosing than various tretinoin creams and gels.
Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. [1999.10]
Tazarotene (AGN 190168) is a new acetylenic retinoid which is effective for the topical treatment of patients with stable plaque psoriasis and mild to moderate acne vulgaris.Thus, topical tazarotene has a low potential for systemic adverse effects and is effective in the treatment of patients with acne and psoriasis.
Retinoid therapy: compatible skin care. [1999.05]
Topically applied tretinoin (a retinoid) has been used for over 25 years to treat acne and disorders of keratinization. Now, tretinoin emollient cream, 0.05% (Renova(R)), may be prescribed for the treatment of photodamaged and chronologically aged skin, in conjunction with appropriate skin care and sun protection routines...
Optimizing therapy: tazarotene in combination with phototherapy. [1999.04]
Phototherapy is often used in combination with other antipsoriatic treatments in an attempt to improve efficacy and reduce patients' cumulative exposure to radiation. Although this aim has been achieved with some combinations, the additional therapies often introduce a potential risk of other tolerability and safety problems.
Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions. [1999.01]
BACKGROUND: Topical retinoic acid (RA) causes irritation of the skin. To prevent this side effect, natural precursors of RA have been proposed. The aim of the present study was to compare the local tolerance profiles of retinol (ROL), retinaldehyde (RAL) and RA... CONCLUSION: The natural retinoids ROL and RAL do have a good tolerance profile, in contrast with the irritating potential of RA.
Antibacterial activity of retinaldehyde against Propionibacterium acnes. [1999.01]
BACKGROUND: Retinaldehyde has been shown to exert antibacterial activity in vitro. AIM: This study evaluates the effect of retinaldehyde on Propionibacterium acnes both in vivo and in vitro... CONCLUSION: The MIC of retinaldehyde against P. acnes suggests a direct antibacterial activity. Daily topical application of 0.05% retinaldehyde is associated with a clear reduction of the P. acnes density.
Topical retinoids in the treatment of aging of the skin. [1999]
Aging of the skin is a complex phenomenon resulting from the interaction of several intrinsic and extrinsic factors [1]. Due to the cosmetic disfigurement it produces and its psychological impact, especially to women, aging of the skin has become an issue of great social significance and concern.Furthermore, overwhelming clinical and histological evidence indicate that skin changes of photoaging can be reversed by the use of topical retinoids [4].
Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions. [1999]
BACKGROUND: Topical retinoic acid (RA) causes irritation of the skin. To prevent this side effect, natural precursors of RA have been proposed. The aim of the present study was to compare the local tolerance profiles of retinol (ROL), retinaldehyde (RAL) and RA... CONCLUSION: The natural retinoids ROL and RAL do have a good tolerance profile, in contrast with the irritating potential of RA.
Metabolism of topical retinaldehyde. [1999]
OBJECTIVE: In order to circumvent the tolerance problems encountered with topical application of retinoic acid - a biologically active metabolite of vitamin A - we performed in various models a series of experiments aimed at assessing the bio-availability of topical retinaldehyde and its conversion into either retinoid stores or biologically active metabolites... CONCLUSION: Topical retinaldehyde can be used as a precursor of endogenous retinoids, since it is converted into both storage and bio-active forms of vitamin A.
Efficacy of topical 0.05% retinaldehyde in skin aging by ultrasound and rheological techniques. [1999]
CONCLUSION: Taken together, the results further suggest that retinaldehyde has counteracting effects on skin aging.
Adapalene 0.1% gel and adapalene 0.1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers. [1998.10]
A randomized, investigator masked, intra individual comparative study was conducted in 30 healthy volunteers to compare the cutaneous effects of adapalene 0.1% gel and adapalene 0.1% cream with their respective vehicles, using tretinoin 0.05% cream (n = 21) or tretinoin 0.1% cream (n = 9) and a tretinoin cream vehicle (n = 30) as controls...
A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing. [1998.07]
The clinical and histological effects of retinyl propionate cream (a retinyl ester) on extrinsic skin ageing (photo-ageing) in man were assessed in a double-blind randomized placebo-controlled study of 80 subjects, individual parameters of this being assessed for each treatment site (face, dorsal right forearm and hand, dorsal left forearm and hand) at intervals throughout the study, while skin surface replicas from sites of fine wrinkling around the eye and skin biopsies from the dorsal right forearm were also regularly reviewed throughout.
Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. [1997.08]
BACKGROUND: The ability of topical tretinoin to improve certain signs of skin photodamage has been shown previously. OBJECTIVE: Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining or further improving photodamaged skin during extended use... CONCLUSION: Both strengths of tretinoin emollient cream (0.05% and 0.01%) appeared safe and effective in the treatment of photodamaged skin during a 48-week treatment period.
Comparative effect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women. [1996.04]
CONCLUSION: Objective non-invasive measurements of the biomechanical properties of facial skin show the superiority of retinoic acid over glycolic acid in improving a deleterious effect of ageing.
Histologic evaluation of the long term effects of tretinoin on photodamaged skin. [1996.03]
Sustained improvement with prolonged topical tretinoin for photodamaged skin has been well documented for up to 22 months of continuous treatment. We now report long-term (4 years) histologic effects of topical tretinoin in photodamaged skin of 27 patients, the longest study to date... Furthermore, the study shows that there are no untoward effects on keratinocytes or melanocytes during long-term use of topical tretinoin.
Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams. [1995.09]
CONCLUSIONS: Tretinoin 0.1% and 0.025% produce similar clinical and histologic changes in patients with photoaging, despite significantly greater incidence of irritation with the higher concentration. The separation between clinical improvement and irritation suggests that mechanisms other than irritation dominate tretinoin-induced repair of photoaging in humans.
Ultrastructural effects of topical tretinoin on dermo-epidermal junction and papillary dermis in photodamaged skin. A controlled study. [1995.06]
We examined the effects of daily topical application of 0.05% tretinoin cream on photodamaged Caucasian facial skin by electron microscopy. Specimens obtained pretreatment, after 6 and 12 months of tretinoin therapy (20 patients), and after 6 months of vehicle treatment (5 patients) were compared in a blinded fashion, with special attention to the dermoepidermal junction and papillary dermis...
Topical tretinoin improves the appearance of photo damaged skin. [1994.01]
A multicentre clinical trial has been conducted to assess the efficacy and safety of tretinoin 0.05% cream (Retin-A) in the treatment of photo-damaged Australian skin. Subjects with cutaneous facial photodamage were randomised to treatment with tretinoin (62) or vehicle (63) cream...
Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin. [1990.10]
We performed a 22-month trial of topical tretinoin (retinoic acid) in the treatment of photoaging... Side effects were limited to a cutaneous retinoid reaction that diminished as therapy proceeded.
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