Condition(s) treated: Melasma

Intervention: Jessner's solution chemical peel (Procedure); Trichloroacetic acid chemical peel (Procedure)

Phase: Phase 4

Enrollment status: Recruiting

Sponsor: Emory University

Principal investigator(s) or official(s):
Carl Washington, MD, Principal Investigator, Affiliation: Emory University Department of Dermatology

Overall contact:
Carl Washington, MD, Phone: 404-778-3354, Email: cwashin@emory.edu

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Official title: Treatment of Melasma With Jessner's Solution Vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Study design: Treatment, Non-Randomized, Open Label, Active Control, Single Group Assignment, Efficacy Study

Primary outcome: Clinical efficacy by clinician's evaluation

Secondary outcome: Efficacy by subject's evaluation

Minimum eligible age: 18 Years. Eligible gender(s): Both.

Criteria:

Inclusion Criteria:

- Adults > 18 years old

- Clinical diagnosis of melasma

- Mental capacity to give informed consent

Exclusion Criteria:

- Pregnancy

- H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone

- Active dermatitis

- Presence of cutaneous infection

Carl Washington, MD, Phone: 404-778-3354, Email: cwashin@emory.edu

Emory University Dermatology Clinic, Atlanta, Georgia 30322, United States; Recruiting
Lynae Stewart, Phone: 404-778-4827
Carl Washington, MD, Principal Investigator
Tracy Bialy, MD, Sub-Investigator
Tanda Lane, MD, Sub-Investigator

Start date: January 2004
Last updated: September 13, 2005

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