Condition(s) treated: Melasma

Intervention: Laser Treatment (Procedure); Acid Peel (Procedure)

Enrollment status: Recruiting

Sponsor: Northwestern University

Principal investigator(s) or official(s):
Murad Alam, MD, Principal Investigator, Affiliation: Northwestern University

Overall contact:
Joslyn Witherspoon, MD, MPH, Phone: 312 695 0281, Email: j-witherspoon@northwestern.edu

The objective of this study is to evaluate laser treatment and acid peel for the treatment of melasma.

Official title: Study of Acid Peel and Laser for the Treatment of Melasma

Study design: Treatment, Randomized, Single Blind (Outcomes Assessor), Active Control, Single Group Assignment, Safety/Efficacy Study

Primary outcome: MASI (Time Frame: 20 weeks)

Secondary outcome: Safety (Time Frame: 20 weeks)

Detailed description: The purpose of this study is to evaluate the safety and efficacy of laser treatment and acid peel for the treatment of melasma.

Minimum eligible age: 18 Years. Maximum eligible age: 75 Years. Eligible gender(s): Both.

Criteria:

Inclusion Criteria:

- Diagnosis of melasma lesion measuring at least 4 square centimeters.

- Age 18-75 years.

- Good health.

- Willingness and ability to understand and provide informed consent for participation

in the study.

- Ability to communicate with the investigator.

- Must be willing to forgo other treatment options for melasma during the course of the

study.

Exclusion Criteria:

- Inability to understand the protocol or to give informed consent.

- Mental illness.

- Under 18 years of age and over 75 years of age.

- Laser treatment in the last 6 months before enrollment.

- Isotretinoin within the past year.

- Lidocaine allergy.

- History of herpes simplex viral infection.

- Concurrent active disease to facial area (i. e acne).

- Bleeding disorder.

- History of abnormal wound healing.

- History of abnormal scarring.

Joslyn Witherspoon, MD, MPH, Phone: 312 695 0281, Email: j-witherspoon@northwestern.edu

Northwestern University Dermatology Department, Chicago, Illinois 60611, United States; Recruiting
Murad Alam, MD, Principal Investigator
Roopal Kundu, MD, Sub-Investigator
Lucile White, MD, Sub-Investigator
David M DiBardino, Sub-Investigator
Alfred Rademaker, PhD, Sub-Investigator
Simon Yoo, MD, Sub-Investigator
Mary Martini, MD, Sub-Investigator
Shadi Zari, MD, Sub-Investigator
Nicolle Martin, MD, Sub-Investigator
Susan Boone, MD, Sub-Investigator
Dennis West, PhD, Sub-Investigator
Joslyn Witherspoon, MD, MPH, Sub-Investigator

Start date: May 2007
End date: December 2008
Last updated: April 18, 2008

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