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You are here: Anti-Aging Skin Treatments > Topical Actives

Topical Skin Rejuvenation Treatments

There are hundreds if not thousands topical skin rejuvenation treatments on the market, from wrinkle creams to eye serums to lifting gels. If all of them worked as advertised, anyone with a bit of extra cash could have a skin of a fifteen year old. In reality, relatively few topical agents are clinically proven to improve wrinkles and other signs of skin aging. Others are supported by some positive evidence but not enough to confidently say that they work. Numerous others aren't backed by any reliable science at all and can even be harmful. As you may know, cosmetics is not regulated by the FDA. Hence it is largely up to the manufacturer's conscience not only to ensure effectiveness but safety as well. Conversely, it is up to the consumer to buy wisely.

Clinically Proven Effective

Tretinoin (Retin A, Renova)
Alpha-hydroxy Acids
Vitamin C
Vitamin C derivatives
Anhydrous vitamin C combo
Vitamin C + E + ferulic acid

Possibly Effective but Need More Research

Retinol / retinyl palmitate
Retinyl retinoate
Copper peptides
Alpha lipoic acid
Coenzyme Q10
Green tea
White tea
MMP inhibitors
Furfuryladenine (Kinetin)
Oat beta-glucan
Hyaluronic acid
Palmitoyl pentapeptide-4 (Matrixyl)
Palmitoyl oligopeptide / tetrapeptide-7 (Matrixyl 3000)

Popular but Unproven

Acetyl hexapeptide-3 (Argireline)
Resveratrol / Sirtuins
Beta-hydroxy acids

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